R
Roko Zaja
Researcher at University of Oxford
Publications - 41
Citations - 1599
Roko Zaja is an academic researcher from University of Oxford. The author has contributed to research in topics: ATP-binding cassette transporter & Medicine. The author has an hindex of 20, co-authored 30 publications receiving 1321 citations. Previous affiliations of Roko Zaja include University of Manchester.
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Journal ArticleDOI
Serine ADP-Ribosylation Depends on HPF1
Juan José Bonfiglio,Pietro Fontana,Qi Zhang,Thomas Colby,Ian Gibbs-Seymour,Ilian Atanassov,Edward Bartlett,Roko Zaja,Ivan Ahel,Ivan Matic +9 more
TL;DR: It is reported that serine ADPr is strictly dependent on histone PARylation factor 1 (HPF1), a recently identified regulator of PARP-1, and proposed that O-linked protein AD Pr is the key signal in PARP/PARP-2-dependent processes that govern genome stability.
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Serine is a new target residue for endogenous ADP-ribosylation on histones
Orsolya Leidecker,Juan José Bonfiglio,Thomas Colby,Qi Zhang,Ilian Atanassov,Roko Zaja,Luca Palazzo,Anna Stockum,Ivan Ahel,Ivan Matic +9 more
TL;DR: This work has identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.
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Processing of protein ADP-ribosylation by Nudix hydrolases.
Luca Palazzo,Benjamin Thomas,Ann-Sofie Jemth,Thomas Colby,Orsolya Leidecker,Karla L. H. Feijs,Roko Zaja,Olga Loseva,Jordi Carreras Puigvert,Ivan Matic,Thomas Helleday,Ivan Ahel +11 more
TL;DR: Human Nudix (nucleoside diphosphate-linked moiety X)-type motif 16 (hNUDT16) represents a new enzyme class that can process protein ADP-ribosylation in vitro, converting it into ribose-5'-phosphate (R5P) tags covalently attached to the modified proteins.
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Characterization of glutathione-S-transferases in zebrafish (Danio rerio).
Branka Glisic,Ivan Mihaljević,Marta Popović,Roko Zaja,Jovica Lončar,Karl Fent,Radmila Kovacevic,Tvrtko Smital +7 more
TL;DR: This study provides the first comprehensive analysis of GST superfamily in zebrafish, presents new insight into distinct functions of individual Gsts, and offers methodological protocols that can be used for further verification of interaction of environmental contaminants with fish Gsts.
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Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays.
Tvrtko Smital,Senka Terzić,Roko Zaja,Ivan Senta,Branka Pivčević,Marta Popović,Iva Mikac,Knut Erik Tollefsen,Kevin V. Thomas,Marijan Ahel +9 more
TL;DR: Ecotoxicity profiling of the investigated samples, including cytotoxicity, chronic toxicity and EROD activity; inhibition of the multixenobiotic resistance (MXR), genotoxicity and estrogenic potential, revealed the most significant contribution of toxic compounds to be present in polar fractions.