Ping Yi

TL;DR: The results uncovered an additional level of transcriptional regulation whereby specific modulations of SRC-3 phosphorylation allow this coactivator to function as a regulatable integrator for diverse signaling pathways in cells.

TL;DR: It is proposed that CARM1 is a dual-function coactivators, as it not only activates transcription by modifying core histone tails but also terminates hormone signaling by disassembly of the coactivator complex.

TL;DR: The Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours and enhancing tumour growth and metastasis.

TL;DR: Cryoelectron microscopy is used to determine the quaternary structure of an active complex of DNA-bound ERα, steroid receptor coactivator 3 (SRC-3/NCOA3), and a secondary coActivator (p300/EP300) and presents structural evidence for the location of activation function 1 (AF-1) in a full-length nuclear receptor, which supports a role for AF-1 in SRC- 3 recruitment.

TL;DR: This study identifies phosphorylated SRC-3Delta4 as a missing adaptor between EGFR and its downstream signaling molecule FAK to coordinately regulate EGF-induced cell migration and reveals that a nuclear receptor coactivator can act in the periphery of a cell to directly mediate activation of an enzyme.