P
Pokrath Hansasuta
Researcher at Chulalongkorn University
Publications - 39
Citations - 1620
Pokrath Hansasuta is an academic researcher from Chulalongkorn University. The author has contributed to research in topics: Cytotoxic T cell & Medicine. The author has an hindex of 12, co-authored 29 publications receiving 1529 citations. Previous affiliations of Pokrath Hansasuta include John Radcliffe Hospital & University of Oxford.
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Journal Article
A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers
Linda C Tan,Nancy H. Gudgeon,Nicola E. Annels,Pokrath Hansasuta,Christopher A. O’Callaghan,Sarah Rowland-Jones,Andrew J. McMichael,Alan B. Rickinson,Margaret F. C. Callan +8 more
TL;DR: It is inferred that direct T cell control of viral replicative lesions is maintained in long term carriers of EBV and is an important component of the immune response to this virus.
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Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific
Pokrath Hansasuta,Tao Dong,Hathairat Thananchai,Michael P. Weekes,Christian B. Willberg,Hatice Aldemir,Sarah Rowland-Jones,Veronique M. Braud +7 more
TL;DR: It is shown that HLA‐A3 and ‐A11 tetramers specifically bind to KIR3DL2*001 transfectants and that this recognition is peptide‐specific and single amino acid substitutions in the nonamer peptide underline a critical role for residue 8 in recognition of KIR 3DL2.
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Dynamics of T Cell Responses in HIV Infection
Victor Appay,Laura Papagno,Celsa A. Spina,Pokrath Hansasuta,Abigail S. King,Louise Jones,Graham S. Ogg,Susan J. Little,Andrew J. McMichael,Douglas D. Richman,Sarah Rowland-Jones +10 more
TL;DR: A detailed analysis of the changes in activation and differentiation undergone by Ag-specific CD8+ T cells, in relation to Ag- specific CD4+ T cell responses, in the context of a human infection: HIV-1 is presented.
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Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
Rusung Tan,Xiao-Ning Xu,Graham S. Ogg,Pokrath Hansasuta,Tao Dong,Tim Rostron,Graz Luzzi,Christopher P. Conlon,Gavin R. Screaton,Andrew J. McMichael,Sarah Rowland-Jones +10 more
TL;DR: It is shown that cells bearing the Gag-specific T-cell receptors were rapidly eliminated within hours of infusion through apoptosis, suggesting that the failure of adoptively transferred HIV-specific CTL to reduce virus load in AIDS may be due to rapid apoptosis of the infused cells.
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Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly-exposed persistently seronegative donors.
SarahL. Rowland-Jones,Tao Dong,Lucy Dorrell,Graham S. Ogg,Pokrath Hansasuta,P. Krausa,Joshua Kimani,S Sabally,Koya Ariyoshi,Julius Oyugi,KellyS. MacDonald,KellyS. MacDonald,Job J. Bwayo,Hilton Whittle,Francis A. Plummer,Francis A. Plummer,AndrewJ. McMichael +16 more
TL;DR: In seropositive donors from Oxford infected with African strains of HIV-1, CTL responses which are specific for particular clades are defined and some unique A clade CTL epitopes are mapped to highly-conserved regions of the virus.