T
Tim Rostron
Researcher at University of Oxford
Publications - 24
Citations - 2881
Tim Rostron is an academic researcher from University of Oxford. The author has contributed to research in topics: Cytotoxic T cell & Epitope. The author has an hindex of 17, co-authored 21 publications receiving 2377 citations. Previous affiliations of Tim Rostron include John Radcliffe Hospital.
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Journal ArticleDOI
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Jose U. Scher,Andrew Sczesnak,Andrew Sczesnak,Randy S. Longman,Randy S. Longman,Nicola Segata,Nicola Segata,Carles Ubeda,Carles Ubeda,Craig M. Bielski,Tim Rostron,Vincenzo Cerundolo,Eric G. Pamer,Steven B. Abramson,Curtis Huttenhower,Dan R. Littman +15 more
TL;DR: The presence of Prevotella copri is identified as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients and uniquePrevotella genes that correlate with disease are identified.
Peer ReviewDOI
Author response: Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Journal ArticleDOI
CD8+ T-cell selection, function, and death in the primary immune response in vivo
Margaret F. C. Callan,Chrysoula Fazou,Hongbing Yang,Tim Rostron,Kathryn Poon,Chris Hatton,Andrew J. McMichael +6 more
TL;DR: Comparison of the clonal composition of primary and memory responses in vivo shows that the clones that dominate the primary response are relatively heavily culled during the downregulation of thePrimary response and the establishment of T-cell memory.
Journal ArticleDOI
Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
Rusung Tan,Xiao-Ning Xu,Graham S. Ogg,Pokrath Hansasuta,Tao Dong,Tim Rostron,Graz Luzzi,Christopher P. Conlon,Gavin R. Screaton,Andrew J. McMichael,Sarah Rowland-Jones +10 more
TL;DR: It is shown that cells bearing the Gag-specific T-cell receptors were rapidly eliminated within hours of infusion through apoptosis, suggesting that the failure of adoptively transferred HIV-specific CTL to reduce virus load in AIDS may be due to rapid apoptosis of the infused cells.
Journal ArticleDOI
Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57.
Geraldine M. Gillespie,Rupert Kaul,Tao Dong,Hongbing Yang,Tim Rostron,Job J. Bwayo,Peter Kiama,Tim E. A. Peto,Francis A. Plummer,Andrew J. McMichael,Sarah Rowland-Jones +10 more
TL;DR: B*5701+ and B5703+ donors demonstrate broad functional cross-reactivity to both common and rare variants of a dominant p24 epitope, which could be relevant to the association of B*57 alleles with slow progression to AIDS.