P
Ponnampalam Gopalakrishnakone
Researcher at National University of Singapore
Publications - 163
Citations - 5933
Ponnampalam Gopalakrishnakone is an academic researcher from National University of Singapore. The author has contributed to research in topics: Venom & Snake venom. The author has an hindex of 43, co-authored 162 publications receiving 5489 citations. Previous affiliations of Ponnampalam Gopalakrishnakone include University of Louisiana at Monroe & Agency for Science, Technology and Research.
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Purification and partial characterization of two cytolysins from a tropical sea anemone, Heteractis magnifica
TL;DR: Two cytolysins, designated as magnificalysins I and II, were purified from a tropical sea anemone, Heteractis magnifica (formerly Radianthus ritteri), and were found to have haemolytic and lethal activities.
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Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus).
Selvanayagam Nirthanan,Eric Charpantier,Ponnampalam Gopalakrishnakone,Matthew C.E. Gwee,Hoon Eng Khoo,L. S. Cheah,R.M. Kini,Daniel Bertrand +7 more
TL;DR: Candoxin produces a novel pattern of neuromuscular blockade in isolated nerve‐muscle preparations and the tibialis anterior muscle of anaesthetized rats and demonstrates a biphasic concentration–response inhibition curve, suggesting that it may exhibit differential affinities for the two binding sites on the muscle (αβγδ) receptor.
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Secretory phospholipase A2 activity in the normal and kainate injected rat brain, and inhibition by a peptide derived from python serum.
Maung Maung Thwin,Wei-Yi Ong,Chee Wai Fong,Kazuki Sato,Kyoko Kodama,Akhlaq A. Farooqui,Ponnampalam Gopalakrishnakone +6 more
TL;DR: Results show that there is a high level of sPLA2 activity in the normal hippocampus, pons, and medulla oblongata, and that the level increases further in the hippocampus after kainate-induced excitotoxic injury.
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Identification and characterization of a phospholipase A2 from the venom of the Saw-scaled viper: Novel bactericidal and membrane damaging activities.
Ramar Perumal Samy,Ponnampalam Gopalakrishnakone,Ho Bow,Peter N. Puspharaj,Vincent T. K. Chow +4 more
TL;DR: It is shown that the toxic effect induced by E. carinatus venom is due to the presence of myotoxic PLA(2) (EcTx-I), which corroborates the hypothesis of an association between toxic and enzymatic domains and displays a heparin binding C-terminal region.
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A major lethal factor of the venom of Burmese Russell's viper (Daboia russelli siamensis): Isolation, n-terminal sequencing and biological activities of daboiatoxin
TL;DR: A major lethal factor, daboiatoxin (DbTx), showing strong PLA2 activity (specific activity 91.7 nmoles/min/mg), was purified to homogeneity from the venom of Burmese Russell's viper (Daboia r. siamensis) by a combination of gel filtration on SephadeX G-75 and ion-exchange chromatography on CM-Sephadex C-25, followed by purification on high-performance