P
Ponnampalam Gopalakrishnakone
Researcher at National University of Singapore
Publications - 163
Citations - 5933
Ponnampalam Gopalakrishnakone is an academic researcher from National University of Singapore. The author has contributed to research in topics: Venom & Snake venom. The author has an hindex of 43, co-authored 162 publications receiving 5489 citations. Previous affiliations of Ponnampalam Gopalakrishnakone include University of Louisiana at Monroe & Agency for Science, Technology and Research.
Papers
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Journal ArticleDOI
Use of the upside-down method to prepare porous polymer films with tunable surface pore sizes.
TL;DR: Porous polyurethane films with well-ordered pores were prepared using polystyrene microspheres as a template, and the surface pore sizes were tuned using a new upside-down (USD) method.
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Cloning and molecular characterization of BmHYA1, a novel hyaluronidase from the venom of Chinese red scorpion Buthus martensi Karsch.
TL;DR: The phylogenetic analysis indicates early divergence and independent evolution of BmHYA1 from other hyaluronidases, as well as potential N-glycosylation sites from scorpion venom.
Journal ArticleDOI
Adrenergic and nitrergic responses of the rat isolated anococcygeus muscle to a new toxin (makatoxin I) from the venom of the scorpion Buthus martensi Karsch.
J.P. Gong,Matthew C.E. Gwee,Ponnampalam Gopalakrishnakone,R. Manjunatha Kini,Maxey C. M. Chung +4 more
TL;DR: The contractile responses of the rat anococcygeus muscle to MkTx I can be attributed to the release of transmitter NA on postjunctional alpha-adrenoceptors, whereas the relaxant responses of of the Acm to Mktx I involve therelease of nitric oxide as the neurotransmitter which, presumably, results in the activation of the enzyme guanylate cyclase leading to relaxation of the muscle.
Journal ArticleDOI
Therapeutic Potential of Peptides with Neutralizing Ability Towards the Venom and Toxin (CaTx-I) of Crotalus adamanteus
Ramar Perumal Samy,Maung Maung Thwin,Bradley G. Stiles,Ho Bow,Vincent T. K. Chow,Ponnampalam Gopalakrishnakone +5 more
TL;DR: The potent snake venom neutralizing properties of peptides were confirmed and produced a significant decrease in lipid peroxidase (LPx) and enhancement of superoxide dismutase (SOD), catalase (CAT) and Glutathione-s-transferase (GST) levels indicating their antioxidant property against venom-induced changes in mice.
Patent
Phospholipase a2 inhibitory peptides from python reticulatus
TL;DR: A phospholipase A2 inhibitor from Python (PIP) was determined from the native protein purified from the blood serum of a nonvenomous snake, Python reticulatus, and given by SEQ ID NO:1.