P
Ponnampalam Gopalakrishnakone
Researcher at National University of Singapore
Publications - 163
Citations - 5933
Ponnampalam Gopalakrishnakone is an academic researcher from National University of Singapore. The author has contributed to research in topics: Venom & Snake venom. The author has an hindex of 43, co-authored 162 publications receiving 5489 citations. Previous affiliations of Ponnampalam Gopalakrishnakone include University of Louisiana at Monroe & Agency for Science, Technology and Research.
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Journal ArticleDOI
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
Maung Maung Thwin,Eleni Douni,Pachiappan Arjunan,George Kollias,Prem V. Kumar,Ponnampalam Gopalakrishnakone +5 more
TL;DR: The results demonstrate the benefit that can be gained from using sPLA2 inhibitory peptide for RA treatment, and validate PIP-18 as a potential therapeutic in a clinically relevant animal model of human arthritis.
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Biochemical and pharmacological characterization of the venom of the black scorpion Heterometrus spinifer.
Selvanayagam Nirthanan,Jeremiah S. Joseph,Ponnampalam Gopalakrishnakone,Hoon Eng Khoo,Li-Sam Cheah,Matthew C.E. Gwee +5 more
TL;DR: The venom of the black scorpion Heterometrus spinifer has not been reported to produce lethal cardiovascular complications, which is well known to result from scorpion envenomation as a consequence of a massive release of catecholamines as discussed by the authors.
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Involvement of the l-arginine-nitric oxide synthase pathway in the relaxant responses of the rat isolated anococcygeus muscle to a scorpion (Leiurus quinquestriatus quinquestriatus) venom
TL;DR: The L-arginie-nitric oxide synthase- Nitric oxide pathway is involved in mediating the marked relaxant responses of the CCh precontracted Acm to LQO.
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Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach.
H.S. Raghavendra Prasad,Z. Qi,Kellathur N. Srinivasan,Kellathur N. Srinivasan,Ponnampalam Gopalakrishnakone +4 more
TL;DR: A basic understanding of the differentially expressed genes is provided along with one of the possible pathway which may have been modulated by the exposure of TTX.
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Influence of vacuum on the formation of porous polymer films via water droplets templating
TL;DR: In this paper, the formation of ordered arrays of micron-sized holes on the surface of polymer films cast from volatile solvents in the presence of humidity in vacuum was reported.