P
Ponnampalam Gopalakrishnakone
Researcher at National University of Singapore
Publications - 163
Citations - 5933
Ponnampalam Gopalakrishnakone is an academic researcher from National University of Singapore. The author has contributed to research in topics: Venom & Snake venom. The author has an hindex of 43, co-authored 162 publications receiving 5489 citations. Previous affiliations of Ponnampalam Gopalakrishnakone include University of Louisiana at Monroe & Agency for Science, Technology and Research.
Papers
More filters
Journal ArticleDOI
Pharmacological effects and pathological changes induced by the venom of Pseudechis australis in isolated skeletal muscle preparations.
TL;DR: The inhibition of neuromuscular function by the venom of P. australis was a consequence of the extensive morphological damage to muscle fibres, motor nerve terminals and cytoplasmic organelles which could be attributed to a direct myotoxic action presumably mediated by the enzymatic action of phospholipase A2 present in the venom.
Journal ArticleDOI
Pharmacological characterization of mikatoxin, an α-neurotoxin isolated from the venom of the New-Guinean small-eyed snake Micropechis ikaheka
Selvanayagam Nirthanan,Rong Gao,Ponnampalam Gopalakrishnakone,Matthew C.E. Gwee,Hoon Eng Khoo,L. S. Cheah,R. Manjunatha Kini +6 more
TL;DR: This study provides strong evidence for the presence of a neurotoxin (mikatoxin) in M. ikaheka venom that produces neuromuscular blockade in skeletal muscle attributable to selective and irreversible antagonism of postsynaptic nicotinic acetylcholine receptors of the neuromumuscular junction and likely contributes to the peripheral neurotoxicity observed in the New-Guinean small-eyed snake.
Journal ArticleDOI
Cytopathic effect of Blastocystis hominis after intramuscular inoculation into laboratory mice
K. T. Moe,Mulkit Singh,Ponnampalam Gopalakrishnakone,L. C. Ho,S. W. Tan,X. Q. Chen,Eu-Hian Yap +6 more
TL;DR: Investigation of the pathogenesis of Blastocystis hominis by intramuscular injection of the organism into experimental mice revealed that B. hominis had a strong chemoattractant activity for PML.
Journal ArticleDOI
Antimicrobial Proteins from Snake Venoms: Direct Bacterial Damage and Activation of Innate Immunity Against Staphylococcus aureus Skin Infection
TL;DR: Protective function of svPLA₂s derived from venoms from Viperidae and Elapidae snakes are novel molecules that can activate important mechanisms of innate immunity in animals to endow them with protection against skin infection caused by S. aureus.
Journal ArticleDOI
Effect of aqueous extract of Tragia involucrata Linn. on acute and subacute inflammation.
Ramar Perumal Samy,Ponnampalam Gopalakrishnakone,Peter J. Houghton,Maung Maung Thwin,Savarimuthu Ignacimuthu +4 more
TL;DR: The results prove that the aqueous leaf extract showed highest antiinflammatory activity in acute and subacute inflammation and also support the usage of traditional claims.