P
Ponnampalam Gopalakrishnakone
Researcher at National University of Singapore
Publications - 163
Citations - 5933
Ponnampalam Gopalakrishnakone is an academic researcher from National University of Singapore. The author has contributed to research in topics: Venom & Snake venom. The author has an hindex of 43, co-authored 162 publications receiving 5489 citations. Previous affiliations of Ponnampalam Gopalakrishnakone include University of Louisiana at Monroe & Agency for Science, Technology and Research.
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Journal ArticleDOI
Autonomic effects of some scorpion venoms and toxins
Matthew C.E. Gwee,Selvanayagam Nirthanan,Hoon Eng Khoo,Ponnampalam Gopalakrishnakone,R. Manjunatha Kini,Li-Sam Cheah +5 more
TL;DR: The autonomic effects of venoms and toxins from several species of scorpions, including the Indian red scorpion Mesobuthus tamulus, the Chinese scorpion Buthus martensi Karsch and the Israeli scorpion Leiurus quinquestriatus quinQuestriatus, and the Asian black scorpions Heterometrus longimanus and Heterometricrus spinifer, belonging to Scorpionidae are reviewed.
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A novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah)
TL;DR: It was demonstrated that this neurotoxin produced analgesia in the dose range of 16-32 ng/g without causing any neurological or muscular deficits, suggesting the possible involvement of the opioid and nitric oxide systems.
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Scorpion venoms as a potential source of novel cancer therapeutic compounds.
TL;DR: This mini-review focuses on the anticancer potential of scorpion venoms and toxins and the possible mechanisms for their antitumor activities.
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Candoxin, a Novel Toxin from Bungarus candidus, Is a Reversible Antagonist of Muscle (αβγδ) but a Poorly Reversible Antagonist of Neuronal α7 Nicotinic Acetylcholine Receptors *
Selvanayagam Nirthanan,Eric Charpantier,Ponnampalam Gopalakrishnakone,Matthew C.E. Gwee,Hoon Eng Khoo,Li-Sam Cheah,Daniel Bertrand,R. Manjunatha Kini,R. Manjunatha Kini +8 more
TL;DR: Candoxin is therefore a novel toxin that shares a common scaffold with long chain α-neurotoxins but possibly utilizes additional functional determinants that assist in recognizing neuronal α7 receptors.
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Non-conventional toxins from Elapid venoms
Selvanayagam Nirthanan,Ponnampalam Gopalakrishnakone,Matthew C.E. Gwee,Hoon Eng Khoo,R.M. Kini +4 more
TL;DR: Non-conventional toxins may be a useful source of ligands with novel biological activity targeting the plethora of neuronal nicotinic receptors as well as other physiological processes.