C
Claude Leclerc
Researcher at French Institute of Health and Medical Research
Publications - 297
Citations - 15655
Claude Leclerc is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Antigen & Epitope. The author has an hindex of 69, co-authored 295 publications receiving 14915 citations. Previous affiliations of Claude Leclerc include Academy of Sciences of the Czech Republic & Pasteur Institute.
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Neonatal adaptive immunity comes of age
TL;DR: This review focuses on the new understanding in mice and, where it is clear that related phenomena occur, in humans.
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Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.
Alexander S. Pym,Alexander S. Pym,Priscille Brodin,Laleh Majlessi,Roland Brosch,Caroline Demangel,Ann Williams,Karen E. Griffiths,Gilles Marchal,Claude Leclerc,Stewart T. Cole +10 more
TL;DR: Mice and guinea pigs vaccinated with the recombinant strain BCG::RD1-2F9 were better protected against challenge with M. tuberculosis, showing less severe pathology and reduced dissemination of the pathogen, as compared with control animals immunized with BCG alone.
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The Adenylate Cyclase Toxin of Bordetella pertussis Binds to Target Cells via the αMβ2 Integrin (Cd11b/Cd18)
Pierre Guermonprez,Nadia Khelef,Eric Blouin,Philippe Rieu,Paola Ricciardi-Castagnoli,Nicole Guiso,Daniel Ladant,Claude Leclerc +7 more
TL;DR: The cellular distribution of CD11b, mostly on neutrophils, macrophages, and dendritic and natural killer cells, supports a role for CyaA in disrupting the early, innate antibacterial immune response.
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Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of Neutrophils
Xiaoming Zhang,Laleh Majlessi,Laleh Majlessi,Edith Dériaud,Edith Dériaud,Claude Leclerc,Claude Leclerc,Richard Lo-Man,Richard Lo-Man +8 more
TL;DR: It is shown that after bacterial stimulation, and in contrast to monocytes and macrophages, murine neutrophils contributed poorly to inflammatory responses; however, they secreted high amounts of the anti-inflammatory cytokine IL-10 in a DAP12 adaptor-Syk kinase and MyD88 adaptor -dependent manner.
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Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence
Priscille Brodin,Laleh Majlessi,Laurent Marsollier,Marien I. de Jonge,Daria Bottai,Caroline Demangel,Jason Hinds,Olivier Neyrolles,Philip D. Butcher,Claude Leclerc,Stewart T. Cole,Roland Brosch +11 more
TL;DR: ESX-1-complemented BCG and M. microti strains were more efficiently engulfed by bone-marrow-derived macrophages than controls, and this may account for the enhanced in vivo growth of ESX- 1-carrying strains.