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Priyanka Verma
Researcher at University of Pennsylvania
Publications - 19
Citations - 1400
Priyanka Verma is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 13, co-authored 18 publications receiving 992 citations. Previous affiliations of Priyanka Verma include Rockefeller University.
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Journal ArticleDOI
Break-induced telomere synthesis underlies alternative telomere maintenance
Robert L. Dilley,Priyanka Verma,Nam Woo Cho,Harrison D. Winters,Anne R. Wondisford,Roger A. Greenberg +5 more
TL;DR: The inception of telomere damage recognition by the break-induced replisome orchestrates homology-directed telomeres maintenance, which underlies ALT telitere maintenance.
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Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype
TL;DR: It is found that Mtb induces the foamy phenotype via targeted manipulation of host cellular metabolism to divert the glycolytic pathway toward ketone body synthesis, and pharmacological targeting of pathways mediating this host-pathogen metabolic crosstalk provides a potential strategy for developing tuberculosis chemotherapy.
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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Hyoung Kim,Haineng Xu,Erin George,Dorothy Hallberg,Sushil Kumar,Veena Jagannathan,Sergey Medvedev,Yasuto Kinose,Kyle Devins,Priyanka Verma,Kevin Ly,Yifan Wang,Roger A. Greenberg,Lauren E. Schwartz,Neil Johnson,Robert B. Scharpf,Gordon B. Mills,Rugang Zhang,Victor E. Velculescu,Eric J. Brown,Fiona Simpkins +20 more
TL;DR: The authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PAR Pi and platinum resistant ovarium cancer PDX models, indicating that PARPi-ATRi is a highly promising strategy for OVCAs that acquire resistance to PARPi and platinum.
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Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis
Pooja Arora,Aneesh Goyal,Vivek T. Natarajan,Eerappa Rajakumara,Priyanka Verma,Radhika Gupta,Malikmohamed Yousuf,Omita A. Trivedi,Debasisa Mohanty,Anil K. Tyagi,Rajan Sankaranarayanan,Rajesh S. Gokhale +11 more
TL;DR: It is demonstrated that an insertion motif dictates formation of acyl-adenylate in FAALs, which are crucial nodes in biosynthetic network of virulent lipids and inhibitors directed against these proteins provide a unique multi-pronged approach of simultaneously disrupting several pathways.
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Noncanonical views of homology-directed DNA repair
TL;DR: How alternative HDR pathways in both prokaryotes and eukaryotes in different contexts are executed is reviewed, specifically focusing on the determinants that dictate competition between them and their relevance to cancers that display complex genomic rearrangements or maintain their telomeres by homology-directed DNA synthesis.