Priyanka Verma

TL;DR: This study exploits metabolic variability within biofilm cells to identify alternate respiratory polyketide quinones from both Mycobacterium smegmatis and Mtb, and reveals a redox-balancing chemicocellular process in microbial physiology.

TL;DR: Using a CRISPR based screen, this work identifies the PAR-binding Snf2-like ATPase, ALC1/CHD1L, as a key determinant of PARPi toxicity in HR-deficient cells, and establishes PAR-dependent chromatin remodeling as a mechanistically distinct aspect ofPARPi responses, implicating A LC1 inhibition as a new approach to overcome therapeutic resistance in HR -deficient cancers.

TL;DR: The identification and characterization of QNS offers a promising target for gene manipulation studies toward the production of novel alkaloid scaffolds and mutagenic studies suggest that this protein might have evolved from an evolutionarily related member of chalcone synthase superfamily by mere substitution of two active site residues.

TL;DR: The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative using Alamar-blue assay (H(37)Rv).

TL;DR: In this paper, the synthesis of three natural macrolides 11-O -methylcorniculatolide A, 11- O -methylisocorniculate A and isocORNICULATOLIDE A is reported using a simple, straight forward and high-yielding route.