Priyanka Verma

TL;DR: The inception of telomere damage recognition by the break-induced replisome orchestrates homology-directed telomeres maintenance, which underlies ALT telitere maintenance.

TL;DR: It is found that Mtb induces the foamy phenotype via targeted manipulation of host cellular metabolism to divert the glycolytic pathway toward ketone body synthesis, and pharmacological targeting of pathways mediating this host-pathogen metabolic crosstalk provides a potential strategy for developing tuberculosis chemotherapy.

TL;DR: The authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PAR Pi and platinum resistant ovarium cancer PDX models, indicating that PARPi-ATRi is a highly promising strategy for OVCAs that acquire resistance to PARPi and platinum.

TL;DR: It is demonstrated that an insertion motif dictates formation of acyl-adenylate in FAALs, which are crucial nodes in biosynthetic network of virulent lipids and inhibitors directed against these proteins provide a unique multi-pronged approach of simultaneously disrupting several pathways.

TL;DR: How alternative HDR pathways in both prokaryotes and eukaryotes in different contexts are executed is reviewed, specifically focusing on the determinants that dictate competition between them and their relevance to cancers that display complex genomic rearrangements or maintain their telomeres by homology-directed DNA synthesis.