Q
Qi Zhang
Researcher at Wuhan University
Publications - 37
Citations - 2730
Qi Zhang is an academic researcher from Wuhan University. The author has contributed to research in topics: Inflammasome & Interferon. The author has an hindex of 15, co-authored 37 publications receiving 1919 citations.
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Journal ArticleDOI
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Yong Xiong,Yuan Liu,Liu Cao,Dehe Wang,Ming Guo,Ao Jiang,Dong Guo,Wenjia Hu,Jiayi Yang,Zhidong Tang,Honglong Wu,Yongquan Lin,Meiyuan Zhang,Qi Zhang,Mang Shi,Yingle Liu,Yu Zhou,Ke Lan,Yu Chen +18 more
TL;DR: The results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/Mip1B.
Journal ArticleDOI
Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.
Weiyong Liu,Qi Zhang,Junbo Chen,Rong Xiang,Huijuan Song,Sainan Shu,Ling Chen,Lu Liang,Jiaxin Zhou,Lei You,Peng Wu,Bo Zhang,Yanjun Lu,Liming Xia,Lu Huang,Yang Yang,Fang Liu,Malcolm G Semple,Benjamin J. Cowling,Ke Lan,Ziyong Sun,Hongjie Yu,Yingle Liu +22 more
TL;DR: A retrospective analysis of routine surveillance data involving children hospitalized in central Wuhan, China, for acute lower respiratory infection in early 2018 found that children with Covid-19 were more likely to be diagnosed with pneumonia than the general population.
Journal ArticleDOI
RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.
Liangjun Chen,Weiyong Liu,Qi Zhang,Ke Xu,Guangming Ye,Weichen Wu,Ziyong Sun,Fang Liu,Kailang Wu,Bo Zhong,Mei Yi,Wenxia Zhang,Yu Chen,Yirong Li,Mang Shi,Ke Lan,Yingle Liu +16 more
TL;DR: Phylogenetic analysis indicates that 2019-nCoV is close to coronaviruses (CoVs) circulating in Rhinolophus (Horseshoe bats), and Evolutionary analysis based on ORF1a/1b, S, and N genes suggests2019-n coV is more likely a novel CoV independently introduced from animals to humans.
Journal ArticleDOI
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection.
Wenbiao Wang,Dingwen Hu,Caifeng Wu,Yuqian Feng,Aixin Li,Weiyong Liu,Yingchong Wang,Keli Chen,Mingfu Tian,Feng Xiao,Qi Zhang,Muhammad Adnan Shereen,Weijie Chen,Pan Pan,Pin Wan,Kailang Wu,Jianguo Wu,Jianguo Wu +17 more
TL;DR: It is demonstrated that the cGAS-STING-NLRP3 signaling is essential for host defense against HSV-1 infection.
Journal ArticleDOI
EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production.
Zhen Luo,Rui Su,Wenbiao Wang,Yicong Liang,Xiaofeng Zeng,Muhammad Adnan Shereen,Nadia Bashir,Qi Zhang,Ling Zhao,Kailang Wu,Yingle Liu,Yingle Liu,Jianguo Wu,Jianguo Wu +13 more
TL;DR: It is proposed that EV71 infects astrocytes of the cerebral cortex in mice and human and triggers TLR7 signaling and IL-6 release, subsequently inducing neural pathogenesis in the brain.