Qinshan Gao

TL;DR: This work uses an integrative systems approach, based on genome-wide RNA interference screening, to identify 295 cellular cofactors required for early-stage influenza virus replication, and identifies those involved in kinase-regulated signalling, ubiquitination and phosphatase activity as the most highly enriched.

TL;DR: The construction of a novel immunogen comprising the conserved influenza HA stalk domain and lacking the globular head is described, which shows that vaccination of mice with a headless HA confers protection to these animals against a lethal influenza virus challenge, and predicts that a single immunization with aHeadless HA vaccine will offer effective protection through several influenza epidemics.

TL;DR: The results support that the packaging of influenza viral genome is a selective process, with a high percentage of virus particles package all eight different segments of viral RNAs.

TL;DR: It is found that upon infection, the viral RNAs from the incoming particles travel together until they reach the nucleus, and this newly characterized step of the genome packaging process demonstrates the precise spatiotemporal regulation of the infection cycle.

TL;DR: The data suggest that budding-competent neuraminidase proteins possess an as-yet-unidentified means of counteracting the antiviral restriction factor tetherin and identify a novel way in which the influenza virus neuraminidsase can contribute to virus release.