S
Suchita Bhattacharyya
Researcher at Salk Institute for Biological Studies
Publications - 7
Citations - 1202
Suchita Bhattacharyya is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Viral entry & Ebola virus. The author has an hindex of 6, co-authored 7 publications receiving 1123 citations. Previous affiliations of Suchita Bhattacharyya include Northwestern University.
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Journal ArticleDOI
Human host factors required for influenza virus replication
Renate König,Silke Stertz,Yingyao Zhou,Atsushi Inoue,H.-Heinrich Hoffmann,Suchita Bhattacharyya,Judith G. Alamares,Donna M. Tscherne,Mila Brum Ortigoza,Yuhong Liang,Qinshan Gao,Shane E. Andrews,Sourav Bandyopadhyay,Paul D. De Jesus,Buu P. Tu,Lars Pache,Crystal Shih,Anthony P. Orth,Ghislain M. C. Bonamy,Loren Miraglia,Trey Ideker,Adolfo García-Sastre,John A. T. Young,Peter Palese,Megan L. Shaw,Sumit K. Chanda +25 more
TL;DR: This work uses an integrative systems approach, based on genome-wide RNA interference screening, to identify 295 cellular cofactors required for early-stage influenza virus replication, and identifies those involved in kinase-regulated signalling, ubiquitination and phosphatase activity as the most highly enriched.
Journal ArticleDOI
Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors
Suchita Bhattacharyya,Anna Zagórska,Erin D. Lew,Bimmi Shrestha,Carla V. Rothlin,John Naughton,Michael S. Diamond,Greg Lemke,John A. T. Young +8 more
TL;DR: It is found that ligand-coated viruses activate TAM receptors on dendritic cells (DCs), dampen type I IFN signaling, and thereby evade host immunity and promote infection.
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Ebola virus uses clathrin-mediated endocytosis as an entry pathway
Suchita Bhattacharyya,Kelly L. Warfield,Gordon Ruthel,Sina Bavari,M. Javad Aman,Thomas J. Hope +5 more
TL;DR: Sensitivity of EbGP pseudotyped HIV as well as infectious EBOV to inhibitors of clathrin suggests that EBOv uses clathin-mediated endocytosis as an entry pathway, and since chlorpromazine inhibits E BOV infection, novel therapeutic modalities could be designed based on this lead compound.
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Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions.
TL;DR: Clathrin-mediated endocytosis was previously implicated as one of the cellular pathways involved in filoviral glycoprotein mediated viral entry into target cells, but an unexpected difference between the clathrin pathway requirements for Ebola GP versus Marburg GP pseudovirion infection is revealed.
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Full-length Ebola glycoprotein accumulates in the endoplasmic reticulum
TL;DR: It is suggested that full-length GP, but not GPΔmucin, accumulates in the ER in close proximity to the nuclear membrane, which may underscore its cytotoxic property.