Qisheng Tang

TL;DR: Somatic gain-of-function USP8 mutations are common and contribute to ACTH overproduction in Cushing's disease and inhibition of USP9 or EGFR is promising for treating USp8-mutated corticotrophin adenoma.

TL;DR: It is demonstrated that not all 1p/19q intact oligodendroglial tumors are astrocytic and co-evaluation of IDH and TERTp mutation could potentially serve as an adjunct for diagnosing 1p/.

TL;DR: The data of the present study suggested that HBs might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche, indicating HB niche dependency for the TICs derivative specification.

TL;DR: WES revealed ATRX, PIK3R1, RB1 and SETD2 as the recurrent mutations in gcGBM and one tumor harbored a mutation in MutS homolog 6 (MSH6) that is a key mismatch repair (MMR) gene.

TL;DR: Zhang et al. as discussed by the authors showed that higher PLCG1 expression was associated with tumor growth and worse prognosis in lower-grade gliomas than in that of IDH mutant (IDHmut) LGGs.