Zhifeng Shi

TL;DR: Somatic gain-of-function USP8 mutations are common and contribute to ACTH overproduction in Cushing's disease and inhibition of USP9 or EGFR is promising for treating USp8-mutated corticotrophin adenoma.

TL;DR: Radiomics is a potentially useful approach for estimating IDH1 mutation status noninvasively using conventional T2-FLAIR MRI images, and the estimation accuracy could potentially be improved by using multiple imaging modalities.

TL;DR: Adult IDH wild-type lower-grade gliomas are prognostically heterogeneous and do not have uniformly poor prognosis.

TL;DR: A set of biocompatible, biodegradable, and biofunctionalizable diffractive optical elements (DOEs) using silk proteins as the building materials is reported.

TL;DR: It is indicated that when combined with IDH status, TERT promoter mutation contributes to prognostic subgroups of lower-grade astrocytic tumors or 1p/19q intact lower- grade gliomas and this may further refine future molecular classification of lower toastrocytomas.