Journal ArticleDOI
Diversity and rearrangement of the human T cell rearranging γ genes: nine germ-line variable genes belonging to two subgroups
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TLDR
Nine T cell gamma variable (V) gene segments isolated from human DNA show that major rearrangements can be observed that are attributable to the five active V gamma genes, and human cells with the phenotype of helper T cells can undergo productive V gamma-J gamma joining.About:
This article is published in Cell.The article was published on 1986-04-25. It has received 308 citations till now. The article focuses on the topics: Gene rearrangement & Pseudogene.read more
Citations
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Identification of a putative second T-cell receptor.
Michael B. Brenner,Michael B. Brenner,Joanne McLean,Deno P. Dialynas,Jack L. Strominger,John A. Smith,Frances L. Owen,Jonathan G. Seidman,Stephen C.Y. Ip,Fred S. Rosen,Michael S. Krangel +10 more
TL;DR: Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appears to be the product of the Tγ gene.
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Human T-cell receptor variable gene segment families.
TL;DR: The traditional numbering of V gene segments in the order of their discovery was continued and changed when in conflict with names of other segments, and the number of more than 150 different TCRBV sequences in the database was reduced to a repertoire of only 47 functional T CRBV gene segments.
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The oncogenic cysteine-rich lim domain protein rbtn2 is essential for erythroid development
Alan J. Warren,William H. Colledge,Mark B. L. Carlton,Martin J. Evans,Andrew J.H. Smith,Terence H. Rabbitts +5 more
TL;DR: In vitro differentiation of yolk sac tissue from homozygous mutant mice and sequentially targeted double-mutant ES cells demonstrates a block to erythroid development, which shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erystroid differentiation.
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The Structure, Function, and Molecular Genetics of the gamma/delta T Cell Receptor
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γδ T cells in cancer.
TL;DR: The current knowledge from both human and mouse studies are integrated to highlight the potential of γδ T cell modulation to improve cancer immunotherapy.
References
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Journal ArticleDOI
Detection of specific sequences among DNA fragments separated by gel electrophoresis.
TL;DR: This paper describes a method of transferring fragments of DNA from agarose gels to cellulose nitrate filters that can be hybridized to radioactive RNA and hybrids detected by radioautography or fluorography.
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The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.
Jeffrey Vieira,Joachim Messing +1 more
TL;DR: A series of plasmid vectors containing the multiple cloning site (MCS7) of M13mp7 has been constructed and a kanamycin-resistance marker has been inserted into the center of the symmetrical MCS7 to yield a restriction-site-mobilizing element (RSM).
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Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing
TL;DR: An approach to DNA sequencing using chain-terminating inhibitors (Sanger et al., 1977) combined with cloning of small fragments of DNA in a single-stranded DNA bacteriophage is described, determining the 2771-nucleotide sequence of the largest MboI restriction enzyme fragment from human mitochondrial DNA.
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T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.
TL;DR: Experiments with both cytotoxic and inducer lymphocytes demonstrated that the T cells had to co-recognize antigen in association with one of these MHC-encoded molecules in order for activation to occur.