R J Parmer

TL;DR: This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons.

TL;DR: It is demonstrated that chromogranin A is a substrate for the endogenous endoproteases PC1 and furin in vivo, and that such processing influences its trafficking into the regulated secretory pathway; furthermore, lack of change in chromoganin B and secretogran in II cleavage after diminution of PCl suggests that the action of PC1 on chromog Granin A may be specific within the chromog Cranin/secretogranIn protein family.

TL;DR: Cerebrospinal fluid dopamine beta-hydroxylase immunoreactivity, while not closely linked to central noradrenergic neuronal activity, is at least in part derived from the central nervous system, and that its measurement may be useful in both the diagnosis and treatment of neurological disease.

TL;DR: It is concluded that heterogeneous, bimodally distributed hemodynamic and biochemical responses to α2-adrenergic blockade in subjects with positive family histories of hypertension suggest a discrete subgroup with early expression of perhaps Mendian traits associated with hypertension itself may be associated with later phenotypes.

TL;DR: The role of serotonin as a mediator of emesis associated with cisplatin is supported and it is suggested that plasma CgA level is a valuable tool in studies of chemotherapy-induced emesis.