Thai Dinh

TL;DR: It is shown that recombinant GDF15 induces weight loss in mice fed a high-fat diet and in nonhuman primates with spontaneous obesity, and it is demonstrated that GDF 15-induced cell signaling requires the interaction of GFRAL with the coreceptor RET.

TL;DR: It is demonstrated that chromogranin A is a substrate for the endogenous endoproteases PC1 and furin in vivo, and that such processing influences its trafficking into the regulated secretory pathway; furthermore, lack of change in chromoganin B and secretogran in II cleavage after diminution of PCl suggests that the action of PC1 on chromog Granin A may be specific within the chromog Cranin/secretogranIn protein family.

TL;DR: The findings suggest that targeting CD47 is an attractive therapeutic anti-cancer approach, however, the anti- cancer activity observed with anti-CD47 mAbs is Fc effector dependent as are the side effects observed on RBC indices.

TL;DR: It is concluded that peptides are differentially co-stored with catecholamines, with greater abundance of CgA in the adrenal medulla and NPY in sympathetic nerve, and the results results in quite different changes in plasma concentrations of the catechlamine storage vesicle peptides.

TL;DR: It is concluded that over-expression of chromogranin A is a variable feature of mammalian genetic hypertension.