R
R J Parmer
Researcher at Veterans Health Administration
Publications - 14
Citations - 743
R J Parmer is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Chromogranin A & Blood pressure. The author has an hindex of 11, co-authored 14 publications receiving 707 citations. Previous affiliations of R J Parmer include United States Department of Veterans Affairs & Vanderbilt University.
Papers
More filters
Journal ArticleDOI
Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
Sushil K. Mahata,Daniel T. O'Connor,Manjula Mahata,Seung Hyun Yoo,Laurent Taupenot,Hongjiang Wu,B. M. Gill,R J Parmer +7 more
TL;DR: This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons.
Journal ArticleDOI
Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway.
TL;DR: It is demonstrated that chromogranin A is a substrate for the endogenous endoproteases PC1 and furin in vivo, and that such processing influences its trafficking into the regulated secretory pathway; furthermore, lack of change in chromoganin B and secretogran in II cleavage after diminution of PCl suggests that the action of PC1 on chromog Granin A may be specific within the chromog Cranin/secretogranIn protein family.
Journal ArticleDOI
Dopamine β-Hydroxylase Immunoreactivity in Human Cerebrospinal Fluid: Properties, Relationship to Central Noradrenergic Neuronal Activity and Variation in Parkinson's Disease and Congenital Dopamine β-Hydroxylase Deficiency
Daniel T. O'Connor,Justine H. Cervenka,Justine H. Cervenka,Richard A. Stone,Richard A. Stone,Gail L. Levine,Gail L. Levine,R J Parmer,R J Parmer,Rebecca E. Franco-Bourland,Ignacio Madrazo,Philip J. Langlais,Philip J. Langlais,David Robertson,Italo Biaggioni +14 more
TL;DR: Cerebrospinal fluid dopamine beta-hydroxylase immunoreactivity, while not closely linked to central noradrenergic neuronal activity, is at least in part derived from the central nervous system, and that its measurement may be useful in both the diagnosis and treatment of neurological disease.
Journal ArticleDOI
Expression of altered alpha2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension.
Dao Tt,Mala T. Kailasam,R J Parmer,Le Hv,Le Verge R,Brian P. Kennedy,Ziegler G,Paul A. Insel,Wright Fa,Daniel T. O'Connor +9 more
TL;DR: It is concluded that heterogeneous, bimodally distributed hemodynamic and biochemical responses to α2-adrenergic blockade in subjects with positive family histories of hypertension suggest a discrete subgroup with early expression of perhaps Mendian traits associated with hypertension itself may be associated with later phenotypes.
Journal ArticleDOI
Plasma chromogranin A: a marker of serotonin release and of emesis associated with cisplatin chemotherapy.
TL;DR: The role of serotonin as a mediator of emesis associated with cisplatin is supported and it is suggested that plasma CgA level is a valuable tool in studies of chemotherapy-induced emesis.