Rachael N. Hewitt

TL;DR: The results suggest that mitochondria are a candidate target for interventions to reduce the deleterious impact of senescence in ageing tissues.

TL;DR: It is shown that nonproliferating senescent cells express and incorporate histone H3.3 and other canonical core histones into a dynamic chromatin landscape and HIRA enforces tumor suppression.

TL;DR: In this article, microtopographical features with nanoscale depths, similar in scale to osteoclast resorption pits, were used to promote in vitro bone formation in basal medium.

TL;DR: It is shown that multinucleate OIS cells originate mostly from failed mitosis, and activated Ras coordinately triggers mitotic disruption and enhanced cell survival to promote formation of multin nucleate senescent cells.

TL;DR: It is suggested that activated Wnt signaling in human nevi delays senescence to promote nevus formation, and thereafter, persistent WNT signaling might undermine senescences-mediated tumor suppression and enhances the probability of malignancy.