Maria Grazia Vizioli

TL;DR: It is shown that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING (cyclic GMP–AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

TL;DR: An extended mitochondria-to-nucleus retrograde signaling pathway that initiates formation of CCF during senescence is outlined and is a potential target for drug-based interventions to inhibit the proaging SASP.

TL;DR: It is shown that nonproliferating senescent cells express and incorporate histone H3.3 and other canonical core histones into a dynamic chromatin landscape and HIRA enforces tumor suppression.

TL;DR: It is demonstrated that the conserved UBN1 Hpc2-related domain (HRD) is a novel H3.3-specific-binding domain that is determinant of H2.1/H4.3 binding and chromatin deposition by the HIRA complex.

TL;DR: The data suggest that loss of IGFBP7 expression has a functional role in thyroid carcinogenesis, and it may represent a possible basis for therapeutic strategies.