Radu Ionita

TL;DR: The chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity are summarized and the mechanisms of action of these compounds are discussed, including their actions on oxidative stress relating to depression.

TL;DR: Findings suggest that the hydroalcoholic extract could be a potent neuropharmacological agent against amnesia via modulating cholinergic activity, neuroinflammation and promoting antioxidant action in the rat hippocampus.

TL;DR: It is suggested that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.

TL;DR: 6-Hydroxy-l-nicotine (6HLN), a nicotine derivative from nicotine degradation by Arthrobacter nicotinovorans pAO1 strain was found to improve behavioral deficits and to reverse oxidative stress in the rat hippocampus, suggesting the use of this compound as an alternative agent in AD treatment.

TL;DR: In this article, a first apoptosis signal ligand (FasL) was induced in mesenchymal stromal cells (MSC) to improve their immunomodulatory activity.