R
Rafael Radi
Researcher at University of the Republic
Publications - 342
Citations - 31694
Rafael Radi is an academic researcher from University of the Republic. The author has contributed to research in topics: Peroxynitrite & Nitric oxide. The author has an hindex of 92, co-authored 319 publications receiving 28403 citations. Previous affiliations of Rafael Radi include Medical College of Wisconsin & University of Pittsburgh.
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Peroxynitrite‐mediated oxidation of albumin to the protein‐thiyl free radical
TL;DR: Peroxynitrite is able to oxidize a protein, bovine serum albumin (BSA), to the corresponding protein‐thiyl free radical as demonstrated by electron paramagnetic resonance (EPR)‐spin‐trapping experiments with both α‐phenyl‐N‐tert‐butyl nitrone (PBN) and 5,5‐dimethyl‐1 ‐pyrroline‐ N‐oxide (DMPO).
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Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.
Florencia Irigoín,Lucía Cibils,Marcelo A. Comini,Shane R. Wilkinson,Leopold Flohé,Rafael Radi +5 more
TL;DR: The evidence suggests a central role of the trypanothione-dependent antioxidant systems in the infection process of T. cruzi, which is associated with increased resistance to macrophage-dependent oxidative killing.
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Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical.
Beatriz Alvarez,Verónica Demicheli,Rosario Durán,Madia Trujillo,Carlos Cerveñansky,Bruce A. Freeman,Rafael Radi +6 more
TL;DR: It is proposed that peroxynitrite reacts with CuZnSOD leading to nitrogen dioxide plus a copper-bound hydroxyl radical species that reacts with histidine residues, forming histidinyl radical.
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Protein tyrosine nitration in hydrophilic and hydrophobic environments.
Silvina Bartesaghi,Gerardo Ferrer-Sueta,Gonzalo Peluffo,Valeria Valez,Hao Zhang,Balaraman Kalyanaraman,Rafael Radi +6 more
TL;DR: Evidence is provided to show that the existence of metal-catalyzed processes, the assistance of nitric oxide-dependent nitration steps and the facilitation by hydrophobic environments, provide individually and/or in combination, feasible scenarios for nitration in complex biological milieux.