R
Rafael Radi
Researcher at University of the Republic
Publications - 342
Citations - 31694
Rafael Radi is an academic researcher from University of the Republic. The author has contributed to research in topics: Peroxynitrite & Nitric oxide. The author has an hindex of 92, co-authored 319 publications receiving 28403 citations. Previous affiliations of Rafael Radi include Medical College of Wisconsin & University of Pittsburgh.
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Journal ArticleDOI
Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes.
Alexandr A. Kapralov,Naveena Yanamala,Yulia Y. Tyurina,Laura Castro,Alejandro K. Samhan-Arias,Yuri A. Vladimirov,Akihiro Maeda,Andrew A. Weitz,Jim Peterson,Danila Mylnikov,Verónica Demicheli,Verónica Tórtora,Judith Klein-Seetharaman,Rafael Radi,Valerian E. Kagan +14 more
TL;DR: The highly conserved Tyr67 is a likely electron-donor (radical acceptor) in the oxygenase half-reaction of the cyt c/CL peroxidase complex, and exerted high resistance to H(2)O(2)-induced oligomerization.
Book ChapterDOI
Peroxynitrite formation from biochemical and cellular fluxes of nitric oxide and superoxide.
Journal ArticleDOI
A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.
Artak Tovmasyan,Clarissa G.C. Maia,Tin Weitner,Sebastián Carballal,Romulo S. Sampaio,Dominik Lieb,Robert K. Ghazaryan,Ivana Ivanović-Burmazović,Gerardo Ferrer-Sueta,Rafael Radi,Júlio S. Rebouças,Ivan Spasojevic,Ludmil Benov,Ines Batinic-Haberle +13 more
TL;DR: The authors' studies provide substantial evidence that Mn(III) N-alkylpyridylporphyrins couple with H2O2 in actions other than catalase-related, and demonstrate the importance of knowing the type and magnitude of reactions that may occur with this intriguing and key species of redoxome.
Journal ArticleDOI
Reaction between Peroxynitrite and Hydrogen Peroxide: Formation of Oxygen and Slowing of Peroxynitrite Decomposition
TL;DR: It is proposed that an activated intermediate of peroxynitrous acid is responsible for hydrogen peroxide oxidation at acidic pH, while at more alkaline pH the formation of a stabilizing complex between hydrogenperoxide and transperoxyn itrite anion is involved.
Journal ArticleDOI
Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi
Florencia Irigoín,Natalia Mayumi Inada,Mariana P. Fernandes,Lucía Piacenza,Fernanda Ramos Gadelha,Anibal E. Vercesi,Rafael Radi +6 more
TL;DR: In this article, the authors established mitochondrial Ca 2+ overload as the link between complement deposition and the observed changes in mitochondrial physiology and the triggering of the epimastigote stage of Trypanosoma cruzi.