Rafael Radi

TL;DR: The different physicochemical conditions found here to influence pKaalk are expected to vary depending on cellular conditions and subcellular localization of the protein, thus determining the existence of alternative conformations of Cyt in vivo.

TL;DR: It is demonstrated that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants, which suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems.

TL;DR: Oxidants have now been implicated in activating apoptosis, suggesting that cells respond to a certain threshold of oxidative stress by activating cell death pathways.

TL;DR: This chapter critically analyze current redox-based therapeutic strategies including the direct action of compounds on •NO-and peroxynitrite-derived reactive species as well as the induction or endogenous antioxidant mechanisms, with the overall goal to cope against nitroxidative stress conditions.

TL;DR: In egg yolk phosphatidylcholine liposomes, nitration was highest for the peptide with tyrosine at position 8 and dramatically increased as a function of oxygen levels.