R
Raffaella Ghittoni
Researcher at University of Siena
Publications - 20
Citations - 1430
Raffaella Ghittoni is an academic researcher from University of Siena. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 14, co-authored 20 publications receiving 1320 citations. Previous affiliations of Raffaella Ghittoni include International Agency for Research on Cancer & University of Arizona.
Papers
More filters
Journal ArticleDOI
The biological properties of E6 and E7 oncoproteins from human papillomaviruses
TL;DR: Most of the findings on the biological properties and molecular mechanisms of the oncoproteins E6 and E7 from mucosal and cutaneous HPV types are reviewed.
Journal ArticleDOI
IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.
Frank D. Vladich,Susan M. Brazille,Debra A. Stern,Michael L. Peck,Raffaella Ghittoni,Raffaella Ghittoni,Donata Vercelli +6 more
TL;DR: The data indicate that natural variation in the coding region of IL13 may be an important genetic determinant of susceptibility to allergy, and suggests that increased allergic inflammation in carriers ofIL13+2044A depends on enhanced IL-13-mediated Th2 effector functions rather than increased Th2 differentiation.
Journal ArticleDOI
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.
Silvia Rossi Paccani,Fiorella Tonello,Raffaella Ghittoni,Mariarita Natale,Lucia Muraro,Mario Milco D'Elios,Wei-Jen Tang,Cesare Montecucco,Cosima T. Baldari +8 more
TL;DR: It is shown that LT and ET are potent suppressors of human T cell activation and proliferation triggered through the antigen receptor, which identifies a novel strategy of immune evasion by B. anthracis based on both effector subunits of the toxic complex and targeted to a key cellular component of adaptive immunity.
Journal ArticleDOI
Role of human papillomaviruses in carcinogenesis.
TL;DR: The demonstration that high-risk HPV types are the etiological agents of cervical cancer allowed the implementation in the clinical routine of novel screening strategies for cervical lesions, as well as the development of a very efficient prophylactic vaccine.
Journal ArticleDOI
Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.
Raffaella Ghittoni,Laura Patrussi,Katja Pirozzi,Michela Pellegrini,P.E. Lazzerini,P. Leopoldo Capecchi,Franco Laghi Pasini,Cosima T. Baldari +7 more
TL;DR: It is reported that simvastatin suppresses T‐cell activation and proliferation as the result of its capacity to inhibit HMG‐CoA reductase, and identifies Ras superfamily GTPases as strategic molecular targets in T‐ cell immunosuppression by statins.