R
Raffaella Sordella
Researcher at Cold Spring Harbor Laboratory
Publications - 50
Citations - 18652
Raffaella Sordella is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Epidermal growth factor receptor & Erlotinib. The author has an hindex of 29, co-authored 50 publications receiving 17748 citations. Previous affiliations of Raffaella Sordella include Cornell University & Watson School of Biological Sciences.
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Journal ArticleDOI
Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
Serif Senturk,Nitin H. Shirole,Nitin H. Shirole,Dawid G. Nowak,Vincenzo Corbo,Debjani Pal,Debjani Pal,Alexander G. Vaughan,David A. Tuveson,Lloyd C. Trotman,Justin B. Kinney,Raffaella Sordella +11 more
TL;DR: It is demonstrated that fusing an FKBP12-derived destabilizing domain to Cas9 (DD-Cas9) enables conditional Cas9 expression and temporal control of gene editing in the presence of an FkBP12 synthetic ligand.
Journal ArticleDOI
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors.
Daniel A. Haber,Daphne W. Bell,Raffaella Sordella,E. L. Kwak,Godin-Heymann Nadia G,Sreenath V. Sharma,Thomas J. Lynch,Jeffrey Settleman +7 more
TL;DR: The molecular and clinical insights derived from targeting EGFR in NSCLC offer important lessons for the broader application of targeted therapeutic agents in solid tumors.
Journal ArticleDOI
SHP-2 Positively Regulates Myogenesis by Coupling to the Rho GTPase Signaling Pathway
Maria I. Kontaridis,Seda Eminaga,Mara Fornaro,Christina Ivins Zito,Raffaella Sordella,Jeffrey Settleman,Anton M. Bennett +6 more
TL;DR: It is demonstrated that myogenesis is critically regulated by the actions of SHP-2 on the p190-B Rho GAP/RhoA pathway.
Journal ArticleDOI
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling
Davide Barberis,Andrea Casazza,Raffaella Sordella,Simona Corso,Stefania Artigiani,Jeff Settleman,Paolo M. Comoglio,Luca Tamagnone +7 more
TL;DR: It is concluded that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins, through interaction with GTPase activating protein (GAP).
Journal ArticleDOI
Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.
Virendra K. Chaudhri,Gregory G. Salzler,Salihah A. Dick,Melanie S. Buckman,Raffaella Sordella,Edward D. Karoly,Robert P. Mohney,Brendon M. Stiles,Olivier Elemento,Nasser K. Altorki,Timothy E. McGraw +10 more
TL;DR: The data suggest that increased autophagy may account for metabolic differences between CAFs and NFs and may play additional as yet undetermined roles in lung cancer.