R
Raffaella Sordella
Researcher at Cold Spring Harbor Laboratory
Publications - 50
Citations - 18652
Raffaella Sordella is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Epidermal growth factor receptor & Erlotinib. The author has an hindex of 29, co-authored 50 publications receiving 17748 citations. Previous affiliations of Raffaella Sordella include Cornell University & Watson School of Biological Sciences.
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Journal ArticleDOI
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
Daphne W. Bell,Ira Gore,Ross A. Okimoto,Godin-Heymann Nadia G,Raffaella Sordella,Roseann Mulloy,Sreenath V. Sharma,Brian W. Brannigan,Gayatry Mohapatra,Jeff Settleman,Daniel A. Haber +10 more
TL;DR: A family with multiple cases of non-small cell lung cancer associated with germline transmission of a specific secondary somatic mutation, EGFR T790M, is described, implicate altered EGFR signaling in genetic susceptibility to lung cancer.
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Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis
TL;DR: Together, these results identify the Rho GTPase as an essential modulator of IGF-1 signals that direct the adipogenesis-myogenesis cell fate decision.
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Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
Ultan McDermott,Sreenath V. Sharma,Lori Dowell,Patricia Greninger,Clara Montagut,Jennifer Lamb,Heidi Archibald,Raul Raudales,Angela Tam,Diana Lee,S. Michael Rothenberg,Jeffrey G. Supko,Raffaella Sordella,Lindsey E. Ulkus,A. John Iafrate,Shyamala Maheswaran,Ching-Ni Njauw,Hensin Tsao,Lisa Drew,Jeff H. Hanke,Xiao-Jun Ma,Mark G. Erlander,Nathanael S. Gray,Daniel A. Haber,Jeffrey Settleman +24 more
TL;DR: Genetically defined cancer subsets, irrespective of tissue type, predict response to kinase inhibitors, and provide an important preclinical model to guide early clinical applications of novel targeted inhibitors.
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TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Zhan Yao,Silvia Fenoglio,Dingcheng Gao,Matthew Camiolo,Brendon M. Stiles,Trine Lindsted,Michaela Schlederer,Christopher Johns,Nasser K. Altorki,Vivek Mittal,Lukas Kenner,Raffaella Sordella +11 more
TL;DR: It is argued that both tumor cell-autonomous mechanisms and/or activation of the tumor microenvironment could contribute to primary and acquired erlotinib resistance, and as such, treatments based on EGFR inhibition may not be sufficient for the effective treatment of lung-cancer patients harboring mutant EGFR.
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A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Prem K. Premsrirut,Prem K. Premsrirut,Lukas E. Dow,Sang Yong Kim,Matthew Camiolo,Matthew Camiolo,Colin D. Malone,Colin D. Malone,Cornelius Miething,Claudio Scuoppo,Claudio Scuoppo,Johannes Zuber,Ross A. Dickins,Ross A. Dickins,Scott C. Kogan,Kenneth R. Shroyer,Raffaella Sordella,Gregory J. Hannon,Gregory J. Hannon,Scott W. Lowe,Scott W. Lowe +20 more
TL;DR: This system provides a cost-effective and scalable platform for the production of RNAi transgenic mice targeting any mammalian gene and validates APC/Wnt and p19(ARF) as potential therapeutic targets in T cell acute lymphoblastic leukemia/lymphoma and lung adenocarcinoma, respectively.