Raffaella Vergura

TL;DR: The effects of in vivo supraspinal NPS in mice are evaluated and it is shown that in vivo NPS produces a unique behavioural profile by increasing wakefulness and exerting anxiolytic‐like effects.

TL;DR: This study identified the amino acid residues of this peptide most important for receptor activation as Thr8-Gly9-Met10, suggesting that the C-terminal region of the peptide maintains importance for in vivo activity.

TL;DR: The present findings demonstrate that UFP-512 behaves as a highly potent and selective agonist at Dop receptors and corroborate the proposal that the selective activation of DOP receptors elicits robust anxiolytic- and antidepressant-like effects in rodents.

TL;DR: It is demonstrated that N/OFQ stimulates human monocyte chemotaxis via NOP receptor activation through the order of potency of agonists and the antagonist selectivity.

TL;DR: UFP‐803 is a potent UT receptor ligand which displays competitive/noncompetitive antagonist behavior depending on the assay, and is less potent than urantide, which displayed reduced residual agonist activity and as such may be a useful pharmacological tool.