D
Donald Van Ryk
Researcher at National Institutes of Health
Publications - 35
Citations - 4307
Donald Van Ryk is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor & Binding site. The author has an hindex of 24, co-authored 33 publications receiving 4140 citations. Previous affiliations of Donald Van Ryk include University of Pennsylvania & Drexel University.
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Journal ArticleDOI
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
Peter D. Kwong,Peter D. Kwong,Michael L. Doyle,Michael L. Doyle,David J. Casper,Claudia Cicala,Stephanie A. Leavitt,Shahzad Majeed,Shahzad Majeed,Tavis D. Steenbeke,Miro Venturi,Irwin Chaiken,Michael Fung,Hermann Katinger,Paul W. I. H. Parren,James E. Robinson,Donald Van Ryk,Liping Wang,Dennis R. Burton,Ernesto Freire,Richard T. Wyatt,Richard T. Wyatt,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson,James Arthos +25 more
TL;DR: It is shown that recognition by receptor-binding-site antibodies induces conformational change, and conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization.
Journal ArticleDOI
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Tongqing Zhou,Ling Xu,Barna Dey,Ann J. Hessell,Donald Van Ryk,Shi Hua Xiang,Xinzhen Yang,Mei-Yun Zhang,Michael B. Zwick,James Arthos,Dennis R. Burton,Dimiter S. Dimitrov,Joseph Sodroski,Richard T. Wyatt,Gary J. Nabel,Peter D. Kwong +15 more
TL;DR: A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.
Journal ArticleDOI
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
James Arthos,Claudia Cicala,Elena Martinelli,Elena Martinelli,Katilyn Macleod,Donald Van Ryk,Danlan Wei,Zhen Xiao,Timothy D. Veenstra,Thomas P Conrad,Richard A. Lempicki,Sherry McLaughlin,Massimiliano Pascuccio,Ravindra Gopaul,Jonathan P. McNally,Catherine C. Cruz,Nina Censoplano,Eva Chung,Kristin N. Reitano,Shyam Kottilil,Diana J. Goode,Anthony S. Fauci +21 more
TL;DR: It is demonstrated here that the HIV-1 envelope protein gp120 bound to an activated form of α4β7, a peptide motif that mimics structures presented by the natural ligands of α 4β7 in the V2 loop of gp120.
Journal ArticleDOI
The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
Claudia Cicala,Elena Martinelli,Jonathan P. McNally,Diana J. Goode,Ravindra Gopaul,Joseph Hiatt,Katija Jelicic,Shyamasundaran Kottilil,Katilyn Macleod,Angeline O'Shea,Nikita Patel,Donald Van Ryk,Danlan Wei,Massimiliano Pascuccio,Ling Yi,Lyle R. McKinnon,Preson Izulla,Joshua Kimani,Rupert Kaul,Anthony S. Fauci,James Arthos +20 more
TL;DR: The specific affinity of gp120 for α4β7 provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.
Journal ArticleDOI
HIV-1 gp120 inhibits TLR9-mediated activation and IFN-α secretion in plasmacytoid dendritic cells
Elena Martinelli,Claudia Cicala,Donald Van Ryk,Diana J. Goode,Katilyn Macleod,James Arthos,Anthony S. Fauci +6 more
TL;DR: It is demonstrated that the direct interaction of HIV-1 gp120 with pDCs interferes with TLR9 activation resulting in a decreased ability of p DCs to secrete antiviral and inflammatory factors that play a central role in initiating host immune responses against invading pathogens.