Kay Nieselt

TL;DR: Three 1,000-year-old mycobacterial genomes from Peruvian human skeletons are presented, revealing that a member of the M. tuberculosis complex caused human disease before contact and implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.

TL;DR: This work introduces EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets and provides features to preprocess, map, authenticate, and assess the quality of ancient DNA samples.

TL;DR: The origins of leprosy bacilli are probed by using a genomic capture-based approach on DNA obtained from skeletal remains from the 10th to 14th centuries, suggesting a link between the middle-eastern and medieval European strains, and remarkable genomic conservation during the past 1000 years.

TL;DR: A high-resolution scRNA-seq expression atlas of the Arabidopsis root composed of thousands of independently profiled cells is presented, revealing key developmental regulators and downstream genes that translate cell fate into distinctive cell shapes and functions.

TL;DR: A survey of the E. coli transcriptome carried out using a differential RNA sequencing approach, which can distinguish between primary and processed transcripts, and an automated prediction algorithm for transcriptional start sites (TSS), finding 14,868 TSS candidates, including 5,574 internal to annotated genes (iTSS) and 5,495 TSS corresponding to potential antisense RNAs (asRNAs).