R
Rainer Spang
Researcher at University of Regensburg
Publications - 171
Citations - 11726
Rainer Spang is an academic researcher from University of Regensburg. The author has contributed to research in topics: Gene expression profiling & Diffuse large B-cell lymphoma. The author has an hindex of 48, co-authored 166 publications receiving 10400 citations. Previous affiliations of Rainer Spang include Max Planck Society & Duke University.
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Journal ArticleDOI
Similarities of ordered gene lists.
TL;DR: A novel algorithm is presented to uncover that two lists of differentially expressed genes are similar, even if these similarities are not apparent to the eye, based on the ordering in the lists.
Journal ArticleDOI
LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys
Tillmann Burghardt,Jürgen Kastner,Hani Suleiman,Eric Rivera-Milla,Natalya Stepanova,Claudio Lottaz,Marion Kubitza,Carsten A. Böger,Sarah M. Schmidt,Mathias Gorski,Uwe de Vries,Helga Schmidt,Irmgard Hertting,Jeffrey B. Kopp,Anne Rascle,Markus Moser,Iris M. Heid,Richard Warth,Rainer Spang,Joachim Wegener,Claudia Tanja Mierke,Christoph Englert,Ralph Witzgall +22 more
TL;DR: It is argued that LMX1B is essential for the maintenance of an appropriately structured actin cytoskeleton in podocytes and knockdown experiments in zebrafish support a model in which LMx1B and ABRA act in a common pathway during pronephros development.
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Integrative normalization and comparative analysis for metabolic fingerprinting by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.
Martin F. Almstetter,Inka J. Appel,Michael Gruber,Claudio Lottaz,Birgit Timischl,Rainer Spang,Katja Dettmer,Peter J. Oefner +7 more
TL;DR: Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry was applied to the comparative metabolic fingerprinting of a wild-type versus a double mutant strain of Escherichia coli lacking the transhydrogenases UdhA and PntAB, confirming true differences in metabolite abundance.
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Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens.
TL;DR: The most frequent mature aggressive B-cell lymphomas are diffuse large B- cell lymphoma (DLBCL) and Burkitt lymphoma and patients suffering from molecularly defined BL but treated with a regimen developed for DLBCL show an unfavorable outcome.
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Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models
Benedict Anchang,Mohammad Javad Sadeh,Juby Jacob,Achim Tresch,Marcel O. Vlad,Peter J. Oefner,Rainer Spang +6 more
TL;DR: An application of D-NEMs to embryonic stem cell development in mice reveals a feed-forward loop dominated network, which stabilizes the differentiated state of cells and points to Nanog as the key sensitizer of stem cells for differentiation stimuli.