R
Rainer Spang
Researcher at University of Regensburg
Publications - 171
Citations - 11726
Rainer Spang is an academic researcher from University of Regensburg. The author has contributed to research in topics: Gene expression profiling & Diffuse large B-cell lymphoma. The author has an hindex of 48, co-authored 166 publications receiving 10400 citations. Previous affiliations of Rainer Spang include Max Planck Society & Duke University.
Papers
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Journal ArticleDOI
Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach
Marcus Wagner,René Hänsel,Sarah Reinke,Julia Richter,Michael Altenbuchinger,Ulf-Dietrich Braumann,Ulf-Dietrich Braumann,Rainer Spang,Markus Löffler,Wolfram Klapper +9 more
TL;DR: A Rudin-Osher-Fatemi filter based segmentation approach for whole tissue samples, combining floating intensity thresholding and rule-based feature detection successfully applied to detection of IHC stained macrophages in DLBCL tissue samples and competes well with existing commercial software kits.
Journal ArticleDOI
Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data
Alexandra Schrader,Katharina Meyer,Neele Walther,Ailine Stolz,Maren Feist,Elisabeth Hand,Frederike von Bonin,Maurits Evers,Christian W. Kohler,Katayoon Shirneshan,Martina Vockerodt,Wolfram Klapper,Monika Szczepanowski,Paul Murray,Holger Bastians,Lorenz Trümper,Rainer Spang,Dieter Kube +17 more
TL;DR: It was found that BCR activation led to a delayed entry to and progression of mitosis and defects in metaphase, and an inverse correlation of BCR.1 genes with c-Myc co-regulated genes in distinct groups of lymphoma patients was observed.
Journal ArticleDOI
Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP
Ron D. Jachimowicz,Wolfram Klapper,Gunther Glehr,Horst Müller,Heinz Haverkamp,Christoph Thorns,Martin-Leo Hansmann,Peter Möller,Harald Stein,Thorsten Rehberg,Bastian von Tresckow,Bastian von Tresckow,Hans Christian Reinhardt,Peter Borchmann,Fong Chun Chan,Rainer Spang,David W. Scott,Andreas Engert,Christian Steidl,Michael Altenbuchinger,Michael Altenbuchinger,Andreas Rosenwald +21 more
TL;DR: In this paper, a gene expression-based predictor in advanced stage CHL patients treated with ABVD does not prove prognostic in 401 BEACOPP-treated advanced stage cHL patients.
Journal ArticleDOI
Melanoma inhibitory activity promotes melanoma development through activation of YBX1
TL;DR: The transcriptional regulation of p54nrb by MIA is characterized to explain MIA's molecular action and effects of MIA on transcriptionalregulation are presented for the first time.
Book ChapterDOI
Permutation filtering: a novel concept for significance analysis of large-scale genomic data
Stefanie Scheid,Rainer Spang +1 more
TL;DR: This work proposes a novel approach to the significance analysis of microarray data, called permutation filtering, and shows that it leads to a more accurate screening, and to more precise estimates of false discovery rates.