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Rainer Spang
Researcher at University of Regensburg
Publications - 171
Citations - 11726
Rainer Spang is an academic researcher from University of Regensburg. The author has contributed to research in topics: Gene expression profiling & Diffuse large B-cell lymphoma. The author has an hindex of 48, co-authored 166 publications receiving 10400 citations. Previous affiliations of Rainer Spang include Max Planck Society & Duke University.
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Journal ArticleDOI
Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse
Antje Schnitter,Christian W. Kohler,Katharina Reddemann,Sarah Reinke,Christoph Thorns,Falko Fend,Birgit Federmann,Peter Möller,Monika Szczepanowski,Rainer Spang,Wolfram Klapper +10 more
TL;DR: The expression of the therapeutic targets CD30, PD1, and PD-L1 can reliably be assessed in tumor specimen at first diagnosis and is unchanged under conventional chemotherapy.
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DTD: An R Package for Digital Tissue Deconvolution.
Marian Schön,Jakob Simeth,Paul Heinrich,Franziska Görtler,Stefan Solbrig,Tilo Wettig,Peter J. Oefner,Michael Altenbuchinger,Rainer Spang +8 more
TL;DR: Loss-function learning adapts DTD to a specific tissue context, such as the deconvolution of blood, or a specific type of tumor tissue, and applies the DTD models to new data.
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Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro.
Sylvia Moeckel,Arabel Vollmann-Zwerenz,Martin Proescholdt,Alexander Brawanski,Markus J. Riemenschneider,Ulrich Bogdahn,Anja-Katrin Bosserhoff,Rainer Spang,Peter Hau +8 more
TL;DR: The gene signature published from a construction set of 18 glioma progenitor cells enhanced for brain tumor initiating cells exhibited good prediction accuracy in cross validation but was not able to validate the signature in an independent validation data set.
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Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation
Antonio Sorrentino,Ayse Nur Menevse,Tillmann Michels,Valentina Volpin,Franziska C. Durst,Julian Sax,Maria Xydia,Abir Hussein,Slava Stamova,Steffen Spoerl,Nicole Heuschneider,Jasmin Muehlbauer,Katharina M. Jeltsch,Anchana Rathinasamy,Melanie Werner-Klein,Marco Breinig,Damian Mikietyn,Christian W. Kohler,Isabel Poschke,Sabrina Purr,Olivia Reidell,Catarina Martins Freire,Rienk Offringa,Claudia Gebhard,Rainer Spang,Michael Rehli,Michael Boutros,Christian Schmidl,Nisit Khandelwal,Philipp Beckhove +29 more
TL;DR: An abundant molecular mechanism is revealed that protects tumor cells from cytotoxic TC attack and pharmacological inhibition of this pathway is feasible, and a SIK3-dependent gene signature of TNF-mediated NF-κB activation was found in a majority of pancreatic cancers where it correlated with increased cytot toxic TC activity and poor prognosis.
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Learning from Embryogenesis-A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development.
Lisa Linck-Paulus,Lisa Lämmerhirt,Daniel Völler,Katharina Meyer,Julia C. Engelmann,Rainer Spang,Norbert Eichner,Gunter Meister,Silke Kuphal,Anja-Katrin Bosserhoff +9 more
TL;DR: In this paper, the authors identify microRNAs (miRNAs) that promote melanoma tumorigenesis and progression, based on an in vitro model of normal human epidermal melanocyte (NHEM) de-differentiation into melanoblast-like cells (MBrCs).