R
Raj Thakrar
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 1714
Raj Thakrar is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Self-healing hydrogels & Acquired immune system. The author has an hindex of 6, co-authored 8 publications receiving 1317 citations. Previous affiliations of Raj Thakrar include Boston Children's Hospital & Harvard University.
Papers
More filters
Journal ArticleDOI
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Omid Veiseh,Joshua C. Doloff,Minglin Ma,Arturo J. Vegas,Hok Hei Tam,Andrew Bader,Jie Li,Erin Langan,Jeffrey Wyckoff,Whitney S. Loo,Siddharth Jhunjhunwala,Alan Chiu,Sean M. Siebert,Katherine Tang,Jennifer Hollister-Lock,Stephanie Aresta-Dasilva,Matthew A. Bochenek,Joshua E. Mendoza-Elias,Yong Wang,Merigeng Qi,Danya M. Lavin,Michael Chen,Nimit Dholakia,Raj Thakrar,Igor Lacík,Gordon C. Weir,Jose Oberholzer,Dale L. Greiner,Robert Langer,Daniel G. Anderson +29 more
TL;DR: In this paper, a broad variety of material classes significantly abrogate foreign body reactions and fibrosis in rodent and non-human primates when the spheres are larger than 1.5 mm in diameter.
Journal ArticleDOI
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Joshua C. Doloff,Joshua C. Doloff,Minglin Ma,Minglin Ma,Minglin Ma,Hok Hei Tam,Kaitlin M. Bratlie,Kaitlin M. Bratlie,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Erin Langan,Erin Langan,Karsten Olejnik,Karsten Olejnik,Patrick Fenton,Patrick Fenton,Jeon Woong Kang,Jennifer Hollister-Locke,Matthew A. Bochenek,Alan Chiu,Alan Chiu,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Thema Vietti,Thema Vietti,Michael Chen,Michael Chen,Josh Cohen,Karolina Siniakowicz,Meirigeng Qi,James J. McGarrigle,Stephen Lyle,David M. Harlan,Dale L. Greiner,Jose Oberholzer,Gordon C. Weir,Robert Langer,Robert Langer,Daniel G. Anderson,Daniel G. Anderson +55 more
TL;DR: This article used a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate.
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Joshua C. Doloff,Joshua C. Doloff,Minglin Ma,Minglin Ma,Minglin Ma,Hok Hei Tam,Kaitlin M. Bratlie,Kaitlin M. Bratlie,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Erin Langan,Erin Langan,Karsten Olejnik,Karsten Olejnik,Patrick Fenton,Patrick Fenton,Jeon Woong Kang,Jennifer Hollister-Locke,Matthew A. Bochenek,Alan Chiu,Alan Chiu,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Thema Vietti,Thema Vietti,Michael Chen,Michael Chen,Josh Cohen,Karolina Siniakowicz,Meirigeng Qi,James J. McGarrigle,Stephen Lyle,David M. Harlan,Dale L. Greiner,Jose Oberholzer,Gordon C. Weir,Robert Langer,Robert Langer,Daniel G. Anderson,Daniel G. Anderson +55 more
TL;DR: A combinatorial approach for covalent chemical modification is used to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate, and identifies three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates.
Journal ArticleDOI
Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
Joshua C. Doloff,Joshua C. Doloff,Omid Veiseh,Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Hok Hei Tam,Shady Farah,Shady Farah,Minglin Ma,Minglin Ma,Minglin Ma,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Alan Chiu,Alan Chiu,Atieh Sadraei,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Marissa Griffin,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Matthew J. Webber,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Michael Chen,Michael Chen,Erin Langan,Erin Langan,Nimit Dholokia,Nimit Dholokia,Raj Thakrar,Raj Thakrar,Meirigeng Qi,Jose Oberholzer,Dale L. Greiner,Robert Langer,Daniel G. Anderson +41 more
TL;DR: Interestingly, colony stimulating factor-1 receptor (CSF1R) is significantly increased following implantation of multiple biomaterial classes: ceramic, polymer and hydrogel, and is revealed as an important mediator of the foreign body reaction and a possible target for fibrosis inhibition.
Journal ArticleDOI
Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation
Minglin Ma,Alan Chiu,Alan Chiu,Gaurav Sahay,Joshua C. Doloff,Joshua C. Doloff,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Joshua Cohen,Arturo J. Vegas,Arturo J. Vegas,Delai Chen,Delai Chen,Kaitlin M. Bratlie,Tram T. Dang,Tram T. Dang,Roger L. York,Roger L. York,Jennifer Hollister-Lock,Gordon C. Weir,Daniel G. Anderson +22 more
TL;DR: In this article, a two-fluid co-axial electro-jetting was used to confine the islets in the core region of the capsules to improve their immuno-protection.