H
Hok Hei Tam
Researcher at Massachusetts Institute of Technology
Publications - 27
Citations - 2981
Hok Hei Tam is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Extracellular vesicle & Fibrosis. The author has an hindex of 15, co-authored 26 publications receiving 2250 citations. Previous affiliations of Hok Hei Tam include Boston Children's Hospital & Ohio State University.
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Journal ArticleDOI
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Omid Veiseh,Joshua C. Doloff,Minglin Ma,Arturo J. Vegas,Hok Hei Tam,Andrew Bader,Jie Li,Erin Langan,Jeffrey Wyckoff,Whitney S. Loo,Siddharth Jhunjhunwala,Alan Chiu,Sean M. Siebert,Katherine Tang,Jennifer Hollister-Lock,Stephanie Aresta-Dasilva,Matthew A. Bochenek,Joshua E. Mendoza-Elias,Yong Wang,Merigeng Qi,Danya M. Lavin,Michael Chen,Nimit Dholakia,Raj Thakrar,Igor Lacík,Gordon C. Weir,Jose Oberholzer,Dale L. Greiner,Robert Langer,Daniel G. Anderson +29 more
TL;DR: In this paper, a broad variety of material classes significantly abrogate foreign body reactions and fibrosis in rodent and non-human primates when the spheres are larger than 1.5 mm in diameter.
Journal ArticleDOI
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Omid Veiseh,Mads Gürtler,Jeffrey R. Millman,Felicia W. Pagliuca,Andrew Bader,Andrew Bader,Andrew Bader,Joshua C. Doloff,Joshua C. Doloff,Jie Li,Jie Li,Michael Chen,Michael Chen,Karsten Olejnik,Karsten Olejnik,Hok Hei Tam,Hok Hei Tam,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Erin Langan,Erin Langan,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Srujan Gandham,Srujan Gandham,James J. McGarrigle,Matthew A. Bochenek,Jennifer Hollister-Lock,Jose Oberholzer,Dale L. Greiner,Gordon C. Weir,Douglas A. Melton,Douglas A. Melton,Robert Langer,Daniel G. Anderson +38 more
TL;DR: The first long-term glycemic correction of a diabetic, immunocompetent animal model using human SC-β cells is reported, which induced glycemic Correction without any immunosuppression until their removal at 174 d after implantation.
Journal ArticleDOI
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Joshua C. Doloff,Joshua C. Doloff,Minglin Ma,Minglin Ma,Minglin Ma,Hok Hei Tam,Kaitlin M. Bratlie,Kaitlin M. Bratlie,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Erin Langan,Erin Langan,Karsten Olejnik,Karsten Olejnik,Patrick Fenton,Patrick Fenton,Jeon Woong Kang,Jennifer Hollister-Locke,Matthew A. Bochenek,Alan Chiu,Alan Chiu,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Thema Vietti,Thema Vietti,Michael Chen,Michael Chen,Josh Cohen,Karolina Siniakowicz,Meirigeng Qi,James J. McGarrigle,Stephen Lyle,David M. Harlan,Dale L. Greiner,Jose Oberholzer,Gordon C. Weir,Robert Langer,Robert Langer,Daniel G. Anderson,Daniel G. Anderson +55 more
TL;DR: This article used a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate.
Journal ArticleDOI
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Hok Hei Tam,Mariane B. Melo,Myungsun Kang,Jeisa M. Pelet,Vera M. Ruda,Maria Hottelet Foley,Joyce K. Hu,Sudha Kumari,Jordan C. Crampton,Alexis D. Baldeon,Rogier W. Sanders,John P. Moore,Shane Crotty,Robert Langer,Daniel G. Anderson,Arup K. Chakraborty,Darrell J. Irvine +16 more
TL;DR: It is found that administering a given total dose of antigen and adjuvant over 1–2 wk through repeated injections or osmotic pumps enhanced humoral responses, with exponentially increasing dosing profiles eliciting >10-fold increases in antibody production relative to bolus vaccination post prime.
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Joshua C. Doloff,Joshua C. Doloff,Minglin Ma,Minglin Ma,Minglin Ma,Hok Hei Tam,Kaitlin M. Bratlie,Kaitlin M. Bratlie,Jie Li,Jie Li,Andrew Bader,Andrew Bader,Erin Langan,Erin Langan,Karsten Olejnik,Karsten Olejnik,Patrick Fenton,Patrick Fenton,Jeon Woong Kang,Jennifer Hollister-Locke,Matthew A. Bochenek,Alan Chiu,Alan Chiu,Sean M. Siebert,Sean M. Siebert,Katherine Tang,Katherine Tang,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Nimit Dholakia,Nimit Dholakia,Raj Thakrar,Raj Thakrar,Thema Vietti,Thema Vietti,Michael Chen,Michael Chen,Josh Cohen,Karolina Siniakowicz,Meirigeng Qi,James J. McGarrigle,Stephen Lyle,David M. Harlan,Dale L. Greiner,Jose Oberholzer,Gordon C. Weir,Robert Langer,Robert Langer,Daniel G. Anderson,Daniel G. Anderson +55 more
TL;DR: A combinatorial approach for covalent chemical modification is used to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate, and identifies three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates.