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Ralph J. DiLeone
Researcher at Yale University
Publications - 115
Citations - 15894
Ralph J. DiLeone is an academic researcher from Yale University. The author has contributed to research in topics: Nucleus accumbens & Lateral hypothalamus. The author has an hindex of 55, co-authored 109 publications receiving 14363 citations. Previous affiliations of Ralph J. DiLeone include Stanford University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions
Manabu Fuchikami,Alexandra M. Thomas,Rong-Jian Liu,Eric S. Wohleb,Benjamin B. Land,Ralph J. DiLeone,George K. Aghajanian,Ronald S. Duman +7 more
TL;DR: It is demonstrated that ketamine infusions or optogenetic stimulation of IL-PFC are sufficient to produce long-lasting antidepressant behavioral and synaptic responses similar to the effects of systemic ketamine administration.
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GABAergic and glutamatergic efferents of the mouse ventral tegmental area
Seth R. Taylor,Sylvia Badurek,Ralph J. DiLeone,Raad Nashmi,Liliana Minichiello,Marina R. Picciotto +5 more
TL;DR: It is found that VTA GABA neurons project widely to forebrain and brainstem targets, including the ventral pallidum, lateral and magnocellular preoptic nuclei, lateral hypothalamus, and lateral habenula, and minor projections also go to central amygdala, mediodorsal thalamus, dorsal raphe, and deep mesencephalicuclei.
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MicroRNAs: A new class of gene regulators
TL;DR: The identification of miRNAs, their biogenesis, and some examples of miRNA effects on biology and disease are reviewed and discussed and emphasis is placed on the possible role for miRNA in nervous system development, function, and disease.
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Medial prefrontal D1 dopamine neurons control food intake
Benjamin B. Land,Nandakumar S. Narayanan,Rong-Jian Liu,Carol A. Gianessi,Catherine E. Brayton,David M Grimaldi,Maysa Sarhan,Douglas J. Guarnieri,Karl Deisseroth,George K. Aghajanian,Ralph J. DiLeone +10 more
TL;DR: A role for D1-type dopamine receptor–expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding is demonstrated and a new circuit for top-down control of food intake is described.
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The Influence of ΔFosB in the Nucleus Accumbens on Natural Reward-Related Behavior
Deanna L. Wallace,Vincent Vialou,Loretta Rios,Tiffany L. Carle-Florence,Sumana Chakravarty,Arvind Kumar,Danielle Graham,Thomas A. Green,Anne Kirk,Sergio D. Iñiguez,Linda I. Perrotti,Linda I. Perrotti,Michel Barrot,Ralph J. DiLeone,Eric J. Nestler,Carlos A. Bolaños-Guzmán +15 more
TL;DR: It is demonstrated that two powerful natural reward behaviors, sucrose drinking and sexual behavior, increase levels of ΔFosB in the NAc, and viral-mediated gene transfer is used to study how such ΔFOSB induction influences behavioral responses to these natural rewards.