R
Ralph J. DiLeone
Researcher at Yale University
Publications - 115
Citations - 15894
Ralph J. DiLeone is an academic researcher from Yale University. The author has contributed to research in topics: Nucleus accumbens & Lateral hypothalamus. The author has an hindex of 55, co-authored 109 publications receiving 14363 citations. Previous affiliations of Ralph J. DiLeone include Stanford University & University of Texas Southwestern Medical Center.
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Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
TL;DR: It is found that dynamic induction and release of BDNF from NAc neurons during cocaine use promotes the development and persistence of addictive behavior and neutralizes endogenous BDNF regulation with intra-NAc infusions of antibody to BDNF.
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Local gene knockdown in the brain using viral-mediated RNA interference
TL;DR: Viral-mediated RNA interference is used to generate a specific knockdown of Th, the gene encoding the dopamine synthesis enzyme tyrosine hydroxylase, within midbrain neurons of adult mice, which resulted in behavioral changes, including a motor performance deficit and reduced response to a psychostimulant.
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Nicotine Decreases Food Intake Through Activation of POMC Neurons
Yann S. Mineur,Alfonso Abizaid,Yan Rao,Ramiro Salas,Ralph J. DiLeone,Daniela Gündisch,Sabrina Diano,Mariella De Biasi,Tamas L. Horvath,Xiao-Bing Gao,Marina R. Picciotto +10 more
TL;DR: It is demonstrated that nicotine decreases food intake and body weight by influencing the hypothalamic melanocortin system and identifies critical molecular and synaptic mechanisms involved in nicotine-induced decreases in appetite.
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Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal
Dan Georgescu,Venetia Zachariou,Michel Barrot,Michel Barrot,Michihiro Mieda,Jon T. Willie,Amelia J. Eisch,Masashi Yanagisawa,Eric J. Nestler,Ralph J. DiLeone +9 more
TL;DR: A role for the orexin system in molecular adaptations to morphine is supported, and dramatic differences in molecular responses among different populations of LH neurons are demonstrated.
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Can Food be Addictive? Public Health and Policy Implications
TL;DR: Although there exist important differences between foods and addictive drugs, ignoring analogous neural and behavioral effects of foods and drugs of abuse may result in increased food-related disease and associated social and economic burdens.