R
Ralph J. DiLeone
Researcher at Yale University
Publications - 115
Citations - 15894
Ralph J. DiLeone is an academic researcher from Yale University. The author has contributed to research in topics: Nucleus accumbens & Lateral hypothalamus. The author has an hindex of 55, co-authored 109 publications receiving 14363 citations. Previous affiliations of Ralph J. DiLeone include Stanford University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance
Dan Georgescu,Robert M. Sears,Robert M. Sears,Jonathan D. Hommel,Michel Barrot,Carlos A. Bolaños,Donald J. Marsh,Maria A. Bednarek,James A. Bibb,Eleftheria Maratos-Flier,Eric J. Nestler,Ralph J. DiLeone,Ralph J. DiLeone +12 more
TL;DR: A novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists is identified and identified, suggesting that these neurons are responsive to a specific set of physiologically relevant conditions.
Journal ArticleDOI
Leptin Mediates the Increase in Blood Pressure Associated with Obesity
Stephanie E. Simonds,Jack T. Pryor,Eric Ravussin,Frank L. Greenway,Ralph J. DiLeone,Andrew M. Allen,Jaspreet K. Bassi,Joel K. Elmquist,Julia M. Keogh,Elana Henning,Martin G. Myers,Julio Licinio,Russell D. Brown,Pablo J. Enriori,Stephen O'Rahilly,Scott M. Sternson,Kevin L. Grove,David Spanswick,David Spanswick,I. Sadaf Farooqi,Michael A. Cowley +20 more
TL;DR: It is demonstrated that leptin couples changes in weight to changes in BP in mammalian species, and humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity.
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RGS9 Modulates Dopamine Signaling in the Basal Ganglia
Zia Ur Rahman,Zia Ur Rahman,Johannes Schwarz,Stephen J. Gold,Stephen J. Gold,Venetia Zachariou,Marc N. Wein,Kwang H. Choi,Abraham Kovoor,Ching-Kang Chen,Ralph J. DiLeone,Sigrid Schwarz,Dana E. Selley,Laura J. Sim-Selley,Michel Barrot,Robert R. Luedtke,David W. Self,Rachael L. Neve,Henry A. Lester,Melvin I. Simon,Eric J. Nestler,Eric J. Nestler +21 more
TL;DR: The data demonstrate a functional interaction between RGS9-2 and D2 receptor signaling and the behavioral actions of psychostimulants and suggest that psychostIMulant induction of RGS 9-2 represents a compensatory adaptation that diminishes drug responsiveness.
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An essential role for DeltaFosB in the nucleus accumbens in morphine action.
Venetia Zachariou,Carlos A. Bolaños,Carlos A. Bolaños,Dana E. Selley,David E. H. Theobald,Michael P. Cassidy,Max B. Kelz,Tamara Z. Shaw-Lutchman,Olivier Berton,Laura J. Sim-Selley,Ralph J. DiLeone,Ralph J. DiLeone,Arvind Kumar,Eric J. Nestler +13 more
TL;DR: It is demonstrated that ΔFosB in the NAc, partly through the repression of dynorphin expression, mediates several major features of opiate addiction.
Journal ArticleDOI
Essential role for RGS9 in opiate action
Venetia Zachariou,Dan Georgescu,Nick Sanchez,Zia Ur Rahman,Ralph J. DiLeone,Olivier Berton,Rachael L. Neve,Laura J. Sim-Selley,Dana E. Selley,Stephen J. Gold,Eric J. Nestler +10 more
TL;DR: These findings establish RGS9 as a potent negative modulator of opiate action in vivo, and suggest that opiate-induced changes in R GS9 levels contribute to the behavioral and neural plasticity associated with chronic opiate administration.