R
Ralph J. DiLeone
Researcher at Yale University
Publications - 115
Citations - 15894
Ralph J. DiLeone is an academic researcher from Yale University. The author has contributed to research in topics: Nucleus accumbens & Lateral hypothalamus. The author has an hindex of 55, co-authored 109 publications receiving 14363 citations. Previous affiliations of Ralph J. DiLeone include Stanford University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia.
Maysa Sarhan,Sophie A. Pawlowski,Sophie A. Pawlowski,Florent Barthas,Florent Barthas,Ipek Yalcin,Jennifer Kaufling,Jennifer Kaufling,Hugues Dardente,Venetia Zachariou,Ralph J. DiLeone,Michel Barrot,Pierre Veinante,Pierre Veinante +13 more
TL;DR: Overall, this study provides evidence that BDNF produced in the parabrachial nucleus modulates the functions of the parABrachio-amygdaloid pathway in opiate analgesia.
Journal ArticleDOI
Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals--results of a pilot study.
Tomoko Udo,Andrea H. Weinberger,Andrea H. Weinberger,Carlos M. Grilo,Kelly D. Brownell,Ralph J. DiLeone,Rachel Lampert,Samantha L. Matlin,Katherine Yanagisawa,Sherry A. McKee,Sherry A. McKee +10 more
TL;DR: This is the first study to demonstrate increased vagal activity in response to food cues in obese individuals compared with non-obese individuals and warrant further investigation on the potential role of vagally-mediated cue reactivity in overeating and obesity.
Posted ContentDOI
Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior
Meghan E. Flanigan,Hossein Aleyasin,Lingjun Li,Charles Joseph Burnett,Kenny L. Chan,Katherine B. LeClair,Elizabeth K. Lucas,Elizabeth K. Lucas,Bridget A. Matikainen-Ankney,William G.M. Janssen,Aki Takahashi,Aki Takahashi,Caroline Menard,Caroline Menard,Madeline L. Pfau,Sam A. Golden,Sylvain Bouchard,Erin S. Calipari,Erin S. Calipari,Eric J. Nestler,Ralph J. DiLeone,Akihiro Yamanaka,George W. Huntley,Roger L. Clem,Scott J. Russo +24 more
TL;DR: Orexin neurons originating from the lateral hypothalamus activate a small population of GABAergic interneurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) to promote aggression and conditioned place preference (CPP) for aggression-paired contexts.
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Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite
TL;DR: The current results indicate that different initiating mechanisms could to lead to similar brain adaptive consequences that underlie the rapid antidepressant responses.
Journal ArticleDOI
Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior
Jazmine D. W. Yaeger,Kevin Krupp,Benjamin Meir Jacobs,Benard Obae Onserio,Brandon Meyerink,Jacob T. Cain,Patrick J. Ronan,Kenneth J. Renner,Ralph J. DiLeone,Cliff H. Summers +9 more
TL;DR: In this article , the role of intra-BLA Orx1R using acute pharmacological inhibition (SB-674042) and genetic knockdown (AAV-U6-Orx 1R-shRNA) strategies was assessed.