R
Ralph Pirow
Researcher at Federal Institute for Risk Assessment
Publications - 25
Citations - 653
Ralph Pirow is an academic researcher from Federal Institute for Risk Assessment. The author has contributed to research in topics: Exposure assessment & Food contact materials. The author has an hindex of 13, co-authored 25 publications receiving 453 citations.
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Journal ArticleDOI
Alternatives to animal testing: current status and future perspectives
Manfred Liebsch,Barbara Grune,Andrea Seiler,Daniel Butzke,Michael Oelgeschläger,Ralph Pirow,Sarah Adler,Christian Riebeling,Andreas Luch +8 more
TL;DR: An overview of the achievements and current tasks, as well as a vision of the future to be addressed by ZEBET@BfR in the years to come is outlined in the present paper.
Journal ArticleDOI
Aggregated aluminium exposure: risk assessment for the general population.
Thomas Tietz,Ariane Lenzner,Anna Elena Kolbaum,S. Zellmer,Christian Riebeling,Rainer Gürtler,Christian Jung,Oliver Kappenstein,Jutta Tentschert,Michael Giulbudagian,Stefan Merkel,Ralph Pirow,Oliver Lindtner,Tewes Tralau,Bernd Schäfer,Peter Laux,Matthias Greiner,Alfonso Lampen,Andreas Luch,Reiner Wittkowski,Andreas Hensel +20 more
TL;DR: The health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs, food additives, food contact materials, and cosmetic products, are assessed.
Journal ArticleDOI
Including Non-Dietary Sources into an Exposure Assessment of the European Food Safety Authority: the challenge of multi-sector chemicals such as Bisphenol A
N. von Goetz,Ralph Pirow,A. Hart,E. Bradley,F. Poças,Davide Arcella,I. T. L. Lillegard,C. Simoneau,J.G.M. van Engelen,Trine Husøy,Anne Theobald,C. Leclercq +11 more
TL;DR: Dietary exposure appears to be the most important exposure source and, based on the central aggregate exposure estimates, contributes around 90% to internal exposure to total BPA and dermal sources may be of equal or even higher toxicological relevance than dietary sources.
Journal ArticleDOI
Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions.
Tewes Tralau,Michael Oelgeschläger,Rainer Gürtler,Gerhard Heinemeyer,Matthias Herzler,Thomas Höfer,Heike Itter,Thomas Kuhl,Nikola Lange,Nicole Lorenz,Christine Müller-Graf,Ulrike Pabel,Ralph Pirow,Vera Ritz,Helmut Schafft,Heiko Schneider,Thomas G. Schulz,David M. Schumacher,S. Zellmer,Gaby Fleur-Böl,Matthias Greiner,Monika Lahrssen-Wiederholt,Alfonso Lampen,Andreas Luch,Gilbert Schönfelder,Roland Solecki,Reiner Wittkowski,Andreas Hensel +27 more
TL;DR: This document summarizes key aspects of this debate in the light of the European “regulatory status quo”, while elucidating new perspectives for regulatory toxicity testing.
Journal ArticleDOI
Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.
Kerstin Reisinger,V. Blatz,Joep Brinkmann,Thomas R. Downs,Anja Fischer,Frank Henkler,Sebastian Hoffmann,Cyrille Krul,Manfred Liebsch,Andreas Luch,Ralph Pirow,Astrid A. Reus,Markus Schulz,Stefan Pfuhler +13 more
TL;DR: The data are intended to demonstrate the use of the 3D Skin Comet assay as a new in vitro tool for following up on positive findings from the standard in vitro genotoxicity test battery for dermally applied chemicals, ultimately helping to drive the regulatory acceptance of the assay.