U
Ulrike Pabel
Researcher at Federal Institute for Risk Assessment
Publications - 25
Citations - 1034
Ulrike Pabel is an academic researcher from Federal Institute for Risk Assessment. The author has contributed to research in topics: Sulfotransferase & Genotoxicity. The author has an hindex of 12, co-authored 19 publications receiving 979 citations.
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Journal ArticleDOI
Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.
Hansruedi Glatt,Heiner Boeing,Christina E.H Engelke,Lan Ma,Andreas Kuhlow,Ulrike Pabel,Doreen Pomplun,Wera Teubner,Walter Meinl +8 more
TL;DR: Cytosolic sulphotransferases transfer the sulpho moiety from the cofactor 5'-phosphoadenosine-3-phosphosulphate to nucleophilic groups of xenobiotics and small endogenous compounds (such as hormones and neurotransmitters).
Journal ArticleDOI
Sulfotransferases: genetics and role in toxicology.
Hansruedi Glatt,Christina E.H Engelke,Ulrike Pabel,Wera Teubner,Alwen L. Jones,Michael W.H. Coughtrie,Ulrich Andrae,Charles N. Falany,Walter Meinl +8 more
TL;DR: Pronounced differences in promutagen activation were also detected between orthologous rat and human SULTs, and between allelic variants of human Sults.
Journal ArticleDOI
Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase
Volker M. Arlt,Hansruedi Glatt,Eva Muckel,Ulrike Pabel,Bernd L. Sorg,Heinz H. Schmeiser,David H. Phillips +6 more
TL;DR: Results indicate that O-acetylation and O-sulfonation by human NATs and SULTs may contribute significantly to the high mutagenic and genotoxic potential of 3-NBA.
Journal ArticleDOI
Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue
TL;DR: It is demonstrated that expression of human SULTs in bacterial and mammalian target cells reinforces the mutagenic activity of aristolochic acids and the possibility that reactive sulphuric acid conjugates produced in other tissues are transferred to kidney and ureter.
Journal ArticleDOI
Sulfation of thyroid hormone by estrogen sulfotransferase.
Monique H. A. Kester,C. H. van Dijk,Dick Tibboel,Alan M. Hood,N. J. M. Rose,Walter Meinl,Ulrike Pabel,Hansruedi Glatt,Charles N. Falany,Michael W.H. Coughtrie,Theo J. Visser +10 more
TL;DR: It is demonstrated for the first time that SULT1E1 catalyzes the facile sulfation of the prohormone T4, the active hormone T3 and the metabolites rT3 and 3,3'-diiodothyronine with preference for rT2 > T3 approximately T4.