R
Randall B. Lauffer
Researcher at Harvard University
Publications - 62
Citations - 10246
Randall B. Lauffer is an academic researcher from Harvard University. The author has contributed to research in topics: Human serum albumin & Nuclear magnetic resonance spectroscopy. The author has an hindex of 31, co-authored 62 publications receiving 9939 citations. Previous affiliations of Randall B. Lauffer include Pennsylvania State University & Cornell University.
Papers
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Journal ArticleDOI
Preclinical evaluation of the pharmacokinetics, biodistribution, and elimination of MS-325, a blood pool agent for magnetic resonance imaging.
TL;DR: The pharmacokinetics and elimination profile of MS-325, including vascular retention and renal excretion, are favorable for use in humans as an intravascular contrast agent for MRI.
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Enzyme-Activated Gd3+ Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement
Alexander Nivorozhkin,Andrew Kolodziej,Peter Caravan,Matthew T. Greenfield,Randall B. Lauffer,Thomas J. McMurry +5 more
TL;DR: Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast agent has been achieved by using prodrug Gd3+ complexes using lysine residues from the prodrug to expose a group that has a high affinity to human serum albumin and promotes enhanced relaxivity, thus enabling the detection of targets at submicromolar concentrations.
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Preparation and water relaxation properties of proteins labeled with paramagnetic metal chelates.
TL;DR: This labeling technique can be used in the preparation of intravascular NMR contrast agents (like paramagnetically-labeled human serum albumin) or target-specific agents (labeled monoclonal antibodies or fibrinogen).
Journal ArticleDOI
MS-325: a small-molecule vascular imaging agent for magnetic resonance imaging.
Randall B. Lauffer,David J. Parmelee,Huillori S. Ouellet,Robert P. Dolan,Hironao Sajiki,Daniel M. Scott,Paul J. Bernard,Erin M. Buchanan,Karen Y. Ong,Zoltan Tyeklar,Katarina Midelfort,Thomas J. McMurry,Richard C. Walovitch +12 more
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Three‐dimensional MRI of coronary arteries using an intravascular contrast agent
TL;DR: This study supports further evaluation of the utility of MS‐325 in improving coronary MR angiography in humans and indicates that the blood signal‐to‐noise ratio increased, depending on the region of interest in which theBlood signal was measured and the precontrast imaging sequence structures.