R
Randall B. Lauffer
Researcher at Harvard University
Publications - 62
Citations - 10246
Randall B. Lauffer is an academic researcher from Harvard University. The author has contributed to research in topics: Human serum albumin & Nuclear magnetic resonance spectroscopy. The author has an hindex of 31, co-authored 62 publications receiving 9939 citations. Previous affiliations of Randall B. Lauffer include Pennsylvania State University & Cornell University.
Papers
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Journal ArticleDOI
1H NMR studies of porcine uteroferrin. Magnetic interactions and active site structure.
TL;DR: Analyses of chemical shifts and the temperature dependence of the paramagnetically shifted resonances indicate that the Fe(III)-Fe(II) cluster in the reduced protein exhibits weak antiferromagnetic exchange coupling, in agreement with the estimate derived from the temperature dependent of the EPR signal intensity.
Journal ArticleDOI
1/T1 NMRD profiles of solutions of Mn2+ and Gd3+ protein-chelate conjugates.
TL;DR: The NMRD profiles (the magnetic field dependence of 1/T1) of solutions of the ternary conjugates differ greatly from those of the corresponding binary ligand‐metal‐ion complexes, both in magnitude and functional form, exhibiting 5‐to 10 fold greater relaxivities and prominent peaks near 20 MHz.
Patent
Diagnostic imaging contrast agents with extended blood retention
TL;DR: In this paper, the authors proposed contrast agents for diagnostic imaging with prolonged blood retention, which are characterized by an image enhancing moiety (IEM), a protein plasma binding moiety, and a blood half-life extending moiety.
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Solution structure and dynamics of lanthanide(III) complexes of diethylenetriaminepentaacetate: a two-dimensional NMR analysis
TL;DR: In this paper, the solution structure and dynamics of lanthanide(III) complexes of diethylenetriaminepentaacetate (DTPA) have been investigated by {sup 1}H NMR.
Journal ArticleDOI
Blood pool agent strongly improves 3D magnetic resonance coronary angiography using an inversion pre-pulse
Mark B.M. Hofman,Robert E. Henson,Sándor J. Kovács,Stefan Fischer,Randall B. Lauffer,Kofi Adzamli,Jan De Becker,Samuel A. Wickline,Christine H. Lorenz +8 more
TL;DR: 3D acquisition was superior to the 2D technique in terms of spatial resolution, SNR of blood, and CNR of blood to myocardium, and the high contrast of the 3D data set allowed for direct and rapid display of coronary arteries using a “closest vessel projection.”