D
David Kokel
Researcher at University of California, San Francisco
Publications - 30
Citations - 2971
David Kokel is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Zebrafish & Caenorhabditis elegans. The author has an hindex of 20, co-authored 30 publications receiving 2519 citations. Previous affiliations of David Kokel include University of Colorado Boulder & Harvard University.
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Journal ArticleDOI
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Jason Rihel,David A. Prober,Anthony C. Arvanites,Kelvin Lam,Steven Zimmerman,Sumin Jang,Stephen J. Haggarty,Stephen J. Haggarty,David Kokel,Lee L. Rubin,Randall T. Peterson,Randall T. Peterson,Alexander F. Schier +12 more
TL;DR: The development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish are reported and it is found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors.
Journal ArticleDOI
Rapid behavior-based identification of neuroactive small molecules in the zebrafish
David Kokel,Jennifer Bryan,Christian Laggner,Rick White,Chung Yan J Cheung,Chung Yan J Cheung,Rita Mateus,Rita Mateus,David Healey,David Healey,Sonia Kim,Sonia Kim,Andreas A. Werdich,Stephen J. Haggarty,Stephen J. Haggarty,Calum A. MacRae,Brian K. Shoichet,Randall T. Peterson,Randall T. Peterson +18 more
TL;DR: By combining HT screening technologies with behavioral phenotyping in vivo, behavior—based chemical screens may accelerate the pace of neuroactive drug discovery and provide small—molecule tools for understanding vertebrate behavior.
Journal ArticleDOI
Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
Nieng Yan,Jijie Chai,Eui Seung Lee,Eui Seung Lee,Lichuan Gu,Qun Liu,Jiaqing He,Jia-Wei Wu,David Kokel,Huilin Li,Quan Hao,Ding Xue,Yigong Shi +12 more
TL;DR: The crystal structure of the CED-4–CED-9 complex is reported at 2.6 Å resolution, and a complete reconstitution of the ced-3 activation pathway is completed using homogeneous proteins of C ED-4, Ced-9 and EGL-1.
Journal ArticleDOI
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell death execution pathways downstream of ced-3 and independent of ced-9
David G. Breckenridge,Byung-Ho Kang,Byung-Ho Kang,David Kokel,Shohei Mitani,L. Andrew Staehelin,Ding Xue +6 more
TL;DR: It is demonstrated that mitochondria dynamics do not regulate apoptosis activation in C. elegans and distinct roles for drp-1 and fis-2 as mediators of cell-death execution downstream of caspase activation are revealed.
Journal ArticleDOI
A non-hallucinogenic psychedelic analogue with therapeutic potential
Lindsay P. Cameron,Robert J. Tombari,Ju Lu,Alexander J. Pell,Zefan Q. Hurley,Yann Ehinger,Maxemiliano V. Vargas,Matthew N. McCarroll,Jack C. Taylor,Douglas Myers-Turnbull,Taohui Liu,Bianca Yaghoobi,Lauren J. Laskowski,Emilie I. Anderson,Guoliang Zhang,Jayashri Viswanathan,Brandon M. Brown,Michelle Tjia,Lee E. Dunlap,Zachary Rabow,Oliver Fiehn,Heike Wulff,John D. McCorvy,Pamela J. Lein,David Kokel,Dorit Ron,Jamie Peters,Yi Zuo,David E. Olson +28 more
TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.