Rebecca Rowan

TL;DR: It is demonstrated that some, but not all, leukemia oncogenes can confer properties of leukemic stem cells to hematopoietic progenitors destined to undergo apoptotic cell death.

TL;DR: It is indicated that Runx1 deficiency has markedly different consequences during development compared with adult hematopoiesis, and insight into the phenotypic manifestations of Runx 1 deficiency in hematoietic malignancies is provided.

TL;DR: In this article, the authors tested the ability of representative leukemia oncogenes to transform committed myeloid progenitor cells that lack the capacity for self-renewal, and showed that an active MOZ-TIF2, but not BCR-ABL, can collaborate with mutations induced by retroviral mutagenesis to confer properties of leukemic stem cells to committed progenitors.

TL;DR: KPC412 is effective for treatment of FIP1L1-PDGFRalpha-induced disease and of imatinib-induced resistance due to the T674I mutation and the potential of alternative kinase inhibitors to overcome resistance in target tyrosine kinases is demonstrated.