R
Regina A. Mangieri
Researcher at University of Texas at Austin
Publications - 36
Citations - 3312
Regina A. Mangieri is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Endocannabinoid system & Anandamide. The author has an hindex of 15, co-authored 31 publications receiving 3127 citations. Previous affiliations of Regina A. Mangieri include University of California, Irvine.
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Journal ArticleDOI
An endocannabinoid mechanism for stress-induced analgesia
Andrea G. Hohmann,Richard L. Suplita,Nathan M. Bolton,Mark H. Neely,Darren Fegley,Regina A. Mangieri,Jocelyn F. Krey,J. Michael Walker,Philip V. Holmes,Jonathon D. Crystal,Andrea Duranti,Andrea Tontini,Marco Mor,Giorgio Tarzia,Daniele Piomelli +14 more
TL;DR: The results indicate that the coordinated release of 2-AG and anandamide in the periaqueductal grey matter might mediate opioid-independent stress-induced analgesia, and identify monoacylglycerol lipase as a previously unrecognized therapeutic target.
Journal ArticleDOI
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Marcello Solinas,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,Andrea Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +16 more
TL;DR: It is shown that URB597, a selective inhibitor of the enzyme fatty-acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Antidepressant-Like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,A. Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +15 more
TL;DR: Gobi et al. as discussed by the authors showed that URB597, a selective inhibitor of the enzyme fatty acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Journal ArticleDOI
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Marco Bortolato,Regina A. Mangieri,Jin Fu,Janet H. Kim,Oliver Arguello,Andrea Duranti,Andrea Tontini,Marco Mor,Giorgio Tarzia,Daniele Piomelli +9 more
TL;DR: URB597 exerts antidepressant-like effects in a highly specific and predictive animal model of depression and these effects may depend on the ability of URB597 to enhance anandamide signaling in select regions of the brain.
Journal ArticleDOI
Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404
Marco Bortolato,Patrizia Campolongo,Regina A. Mangieri,Maria Luisa Scattoni,Roberto Frau,Viviana Trezza,Giovanna La Rana,Roberto Russo,Antonio Calignano,Gian Luigi Gessa,Vincenzo Cuomo,Daniele Piomelli +11 more
TL;DR: A role of anandamide in the regulation of emotion is supported and the an andamide transport system is pointed to as a potential target for anxiolytic drugs.